Cargando…

Lengthening adalimumab dosing interval in quiescent Crohn’s disease patients: protocol for the pragmatic randomised non-inferiority LADI study

INTRODUCTION: Adalimumab is effective for maintenance of remission in patients with Crohn’s disease (CD) at a dose of 40 mg subcutaneously every 2 weeks. However, adalimumab is associated with (long-term) adverse events and is costly. The aim of this study is to demonstrate non-inferiority and cost-...

Descripción completa

Detalles Bibliográficos
Autores principales:	Smits, L J T, Pauwels, R W M, Kievit, W, de Jong, D J, de Vries, A C, Hoentjen, F, van der Woude, C J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2020
Materias:	Gastroenterology and Hepatology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7259868/ https://www.ncbi.nlm.nih.gov/pubmed/32461297 http://dx.doi.org/10.1136/bmjopen-2019-035326

Ejemplares similares

Low-dose naltrexone for the induction of remission in patients with mild to moderate Crohn’s disease: protocol for the randomised, double-blinded, placebo-controlled, multicentre LDN Crohn study
por: Paulides, Emma, et al.
Publicado: (2022)

Control Crohn Safe with episodic adalimumab monotherapy as first-line treatment study (CoCroS): study protocol for a randomised controlled trial
por: Janssen, Laura, et al.
Publicado: (2021)

Protocol for a multinational risk-stratified randomised controlled trial in paediatric Crohn’s disease: methotrexate versus azathioprine or adalimumab for maintaining remission in patients at low or high risk for aggressive disease course
por: Harris, Rachel E, et al.
Publicado: (2020)

Efficacy of anti-TNF dosing interval lengthening in adolescents and young adults with inflammatory bowel disease in sustained remission (FREE-study): protocol for a partially randomised patient preference trial
por: Bouhuys, Marleen, et al.
Publicado: (2021)

Cost-Effectiveness Analysis of Increased Adalimumab Dose Intervals in Crohn’s Disease Patients in Stable Remission: The Randomized Controlled LADI Trial
por: Jansen, Fenna M, et al.
Publicado: (2023)

Cohort profile: design and first results of the Dutch IBD Biobank: a prospective, nationwide biobank of patients with inflammatory bowel disease
por: Spekhorst, Lieke M, et al.
Publicado: (2017)

The Crohn's disease: associated ATG16L1 variant and Salmonella invasion
por: Messer, Jeannette S, et al.
Publicado: (2013)

Acupuncture for Crohn’s disease: a protocol for systematic review and meta-analysis
por: Han, Qiang, et al.
Publicado: (2023)

A novel role of prognostic nutritional index in predicting the effectiveness of infliximab in Crohn's disease
por: Peng, Ziheng, et al.
Publicado: (2023)

Predictors of necessity for endoscopic balloon dilatation in patients with Crohn’s disease-related small bowel stenosis
por: Hayashi, Yukie, et al.
Publicado: (2021)

Factors associated with poor compliance amongst hospitalized, predominantly adolescent pediatric Crohn’s disease patients
por: Cohen, Nathaniel A., et al.
Publicado: (2022)

Clinical effectiveness of pharmacy-led versus conventionally delivered antiviral treatment for hepatitis C in patients receiving opioid substitution therapy: a study protocol for a pragmatic cluster randomised trial
por: Radley, Andrew, et al.
Publicado: (2018)

Heterogeneity in pharmacological treatment and outcomes in Crohn’s disease patients in Catalonia: a population-based observational study
por: Brunet, Eduard, et al.
Publicado: (2022)

Prospective randomised controlled trial of adults with perianal fistulising Crohn’s disease and optimised therapeutic infliximab levels: PROACTIVE trial study protocol
por: Gu, Bonita, et al.
Publicado: (2021)

Diagnostic value of the antiglycoprotein-2 antibody for Crohn’s disease: a PRISMA-compliant systematic review and meta-analysis
por: Deng, Chuiwen, et al.
Publicado: (2017)

Effects of ileocolonic delivered vitamin B(2), B(3) and C (ColoVit) or the Groningen anti-inflammatory diet on disease course and microbiome of patients with Crohn’s disease (VITA-GrAID study): a protocol for a randomised and partially blinded trial
por: Otten, Antonius Timotheus, et al.
Publicado: (2023)

Nurse-led clinic for patients with liver cirrhosis—effects on health-related quality of life: study protocol of a pragmatic multicentre randomised controlled trial
por: Hjorth, Maria, et al.
Publicado: (2018)

Is liver transplantation ‘out-of-hours’ non-inferior to ‘in-hours’ transplantation? A retrospective analysis of the UK Transplant Registry
por: Halliday, Neil, et al.
Publicado: (2019)

Life-event stress induced by the Great East Japan Earthquake was associated with relapse in ulcerative colitis but not Crohn's disease: a retrospective cohort study
por: Shiga, Hisashi, et al.
Publicado: (2013)

Test accuracy of drug and antibody assays for predicting response to antitumour necrosis factor treatment in Crohn’s disease: a systematic review and meta-analysis
por: Freeman, Karoline, et al.
Publicado: (2017)

PRedicting Outcomes For Crohn’s dIsease using a moLecular biomarkEr (PROFILE): protocol for a multicentre, randomised, biomarker-stratified trial
por: Parkes, Miles, et al.
Publicado: (2018)

Is disease activity associated with social support and psychological distress in Crohn’s disease patients? Results of a cross-sectional study in a Chinese hospital population
por: Huang, Mengting, et al.
Publicado: (2023)

Discontinuation of infliximab therapy in patients with Crohn's disease in sustained complete remission (the STOP IT study): protocol for a double-blind, randomised, placebo-controlled, multicentre trial
por: Buhl, Sine Schnoor, et al.
Publicado: (2014)

Efficacy of quadruple regimen with polaprezinc for gastric Helicobacter pylori infection eradication: protocol for a single-centre, single-blind, non-inferiority, randomised clinical trial
por: Wu, Dingkun, et al.
Publicado: (2020)

Protocol for a double-blind, randomised, placebo-controlled pilot study for assessing the feasibility and efficacy of faecal microbiota transplant in a paediatric Crohn’s disease population: PediCRaFT Trial
por: Pai, Nikhil, et al.
Publicado: (2019)

Proactive infliximab optimisation using a pharmacokinetic dashboard versus standard of care in patients with Crohn’s disease: study protocol for a randomised, controlled, multicentre, open-label study (the OPTIMIZE trial)
por: Papamichael, Konstantinos, et al.
Publicado: (2022)

Value-based care pathway for inflammatory bowel disease: a protocol for the multicentre longitudinal non-randomised parallel cluster IBD Value study with baseline period
por: van Linschoten, Reinier Cornelis Anthonius, et al.
Publicado: (2022)

Not Everything That Ulcerates Is Crohn's Disease
por: Afecto, Edgar, et al.
Publicado: (2022)

Trial protocol: a randomised controlled trial to verify the non-inferiority of a partially covered self-expandable metal stent to an uncovered self-expandable metal stent for biliary drainage during neoadjuvant therapy in patients with pancreatic cancer with obstructive jaundice (PUN-NAC trial)
por: Kuwatani, Masaki, et al.
Publicado: (2021)

ATTIRE: Albumin To prevenT Infection in chronic liveR failurE: study protocol for a single-arm feasibility trial
por: China, Louise, et al.
Publicado: (2016)

An Unusual Endoscopic Finding of Gastric Crohn's Disease
por: Garrido, Isabel, et al.
Publicado: (2021)

Study protocol for a multicentre nationwide prospective cohort study to investigate the natural course and clinical outcome in benign liver tumours and cysts in the Netherlands: the BELIVER study
por: Furumaya, Alicia, et al.
Publicado: (2022)

Evaluation of plasma microRNA-122, high-mobility group box 1 and keratin-18 concentrations to stratify acute gallstone disease: a pilot observational cohort study in an emergency general surgery unit
por: Th’ng, Francesca, et al.
Publicado: (2018)

NSAIDs, statins, low-dose aspirin and PPIs, and the risk of oesophageal adenocarcinoma among patients with Barrett's oesophagus: a population-based case–control study
por: Masclee, Gwen M C, et al.
Publicado: (2015)

Accuracy of endoscopic staging and targeted biopsies for routine gastric intestinal metaplasia and gastric atrophy evaluation study protocol of a prospective, cohort study: the estimate study
por: Nieuwenburg, Stella A V, et al.
Publicado: (2019)

Small Bowel Stricture Mimicking Megacolon in a Patient with Crohn's Disease
por: Fernandes, Samuel Raimundo, et al.
Publicado: (2016)

Ablation with irreversible electroporation in patients with advanced perihilar cholangiocarcinoma (ALPACA): a multicentre phase I/II feasibility study protocol
por: Coelen, Robert J S, et al.
Publicado: (2017)

Incidence of household transmission of acute gastroenteritis (AGE) in a primary care sentinel network (1992–2017): cross-sectional and retrospective cohort study protocol
por: de Lusignan, Simon, et al.
Publicado: (2018)

Estimation of fibrosis progression rates for chronic hepatitis C: a systematic review and meta-analysis update
por: Erman, Aysegul, et al.
Publicado: (2019)

Direct targeting of risk factors significantly increases the detection of liver cirrhosis in primary care: a cross-sectional diagnostic study utilising transient elastography
por: Harman, David J, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_bn442lcolni6uavj3864esv1vu