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Reliable Analysis of Clinical Tumor-Only Whole-Exome Sequencing Data

PURPOSE: Allele-specific copy number alteration (CNA) analysis is essential to study the functional impact of single-nucleotide variants (SNVs) and the process of tumorigenesis. However, controversy over whether it can be performed with sufficient accuracy in data without matched normal profiles and...

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Detalles Bibliográficos
Autores principales:	Oh, Sehyun, Geistlinger, Ludwig, Ramos, Marcel, Morgan, Martin, Waldron, Levi, Riester, Markus
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Clinical Oncology 2020
Materias:	Original Reports
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7259876/ https://www.ncbi.nlm.nih.gov/pubmed/32282230 http://dx.doi.org/10.1200/CCI.19.00130

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