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Temporal pressure enhanced topical drug delivery through micropore formation
Transdermal drug delivery uses chemical, physical, or biochemical enhancers to cross the skin barrier. However, existing platforms require high doses of chemical enhancers or sophisticated equipment, use fragile biomolecules, or are limited to a certain type of drug. Here, we report an innovative me...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Association for the Advancement of Science
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7259933/ https://www.ncbi.nlm.nih.gov/pubmed/32523993 http://dx.doi.org/10.1126/sciadv.aaz6919 |
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author | Lio, Daniel Chin Shiuan Chia, Rui Ning Kwek, Milton Sheng Yi Wiraja, Christian Madden, Leigh Edward Chang, Hao Khadir, S. Mohideen Abdul Wang, Xiaomeng Becker, David L. Xu, Chenjie |
author_facet | Lio, Daniel Chin Shiuan Chia, Rui Ning Kwek, Milton Sheng Yi Wiraja, Christian Madden, Leigh Edward Chang, Hao Khadir, S. Mohideen Abdul Wang, Xiaomeng Becker, David L. Xu, Chenjie |
author_sort | Lio, Daniel Chin Shiuan |
collection | PubMed |
description | Transdermal drug delivery uses chemical, physical, or biochemical enhancers to cross the skin barrier. However, existing platforms require high doses of chemical enhancers or sophisticated equipment, use fragile biomolecules, or are limited to a certain type of drug. Here, we report an innovative methodology based on temporal pressure to enhance the penetration of all kinds of drugs, from small molecules to proteins and nanoparticles (up to 500 nm). The creation of micropores (~3 μm(2)) on the epidermal layer through a temporal pressure treatment results in the elevated expression of gap junctions, and reduced expression of occludin tight junctions. A 1 min treatment of 0.28-MPa allows nanoparticles (up to 500 nm) and macromolecules (up to 20 kDa) to reach a depth of 430-μm into the dermal layer. Using, as an example, the delivery of insulin through topical application after the pressure treatment yields up to 80% drop in blood glucose in diabetic mice. |
format | Online Article Text |
id | pubmed-7259933 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | American Association for the Advancement of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-72599332020-06-09 Temporal pressure enhanced topical drug delivery through micropore formation Lio, Daniel Chin Shiuan Chia, Rui Ning Kwek, Milton Sheng Yi Wiraja, Christian Madden, Leigh Edward Chang, Hao Khadir, S. Mohideen Abdul Wang, Xiaomeng Becker, David L. Xu, Chenjie Sci Adv Research Articles Transdermal drug delivery uses chemical, physical, or biochemical enhancers to cross the skin barrier. However, existing platforms require high doses of chemical enhancers or sophisticated equipment, use fragile biomolecules, or are limited to a certain type of drug. Here, we report an innovative methodology based on temporal pressure to enhance the penetration of all kinds of drugs, from small molecules to proteins and nanoparticles (up to 500 nm). The creation of micropores (~3 μm(2)) on the epidermal layer through a temporal pressure treatment results in the elevated expression of gap junctions, and reduced expression of occludin tight junctions. A 1 min treatment of 0.28-MPa allows nanoparticles (up to 500 nm) and macromolecules (up to 20 kDa) to reach a depth of 430-μm into the dermal layer. Using, as an example, the delivery of insulin through topical application after the pressure treatment yields up to 80% drop in blood glucose in diabetic mice. American Association for the Advancement of Science 2020-05-29 /pmc/articles/PMC7259933/ /pubmed/32523993 http://dx.doi.org/10.1126/sciadv.aaz6919 Text en Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). http://creativecommons.org/licenses/by-nc/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license (http://creativecommons.org/licenses/by-nc/4.0/) , which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited. |
spellingShingle | Research Articles Lio, Daniel Chin Shiuan Chia, Rui Ning Kwek, Milton Sheng Yi Wiraja, Christian Madden, Leigh Edward Chang, Hao Khadir, S. Mohideen Abdul Wang, Xiaomeng Becker, David L. Xu, Chenjie Temporal pressure enhanced topical drug delivery through micropore formation |
title | Temporal pressure enhanced topical drug delivery through micropore formation |
title_full | Temporal pressure enhanced topical drug delivery through micropore formation |
title_fullStr | Temporal pressure enhanced topical drug delivery through micropore formation |
title_full_unstemmed | Temporal pressure enhanced topical drug delivery through micropore formation |
title_short | Temporal pressure enhanced topical drug delivery through micropore formation |
title_sort | temporal pressure enhanced topical drug delivery through micropore formation |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7259933/ https://www.ncbi.nlm.nih.gov/pubmed/32523993 http://dx.doi.org/10.1126/sciadv.aaz6919 |
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