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Temporal pressure enhanced topical drug delivery through micropore formation

Transdermal drug delivery uses chemical, physical, or biochemical enhancers to cross the skin barrier. However, existing platforms require high doses of chemical enhancers or sophisticated equipment, use fragile biomolecules, or are limited to a certain type of drug. Here, we report an innovative me...

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Autores principales: Lio, Daniel Chin Shiuan, Chia, Rui Ning, Kwek, Milton Sheng Yi, Wiraja, Christian, Madden, Leigh Edward, Chang, Hao, Khadir, S. Mohideen Abdul, Wang, Xiaomeng, Becker, David L., Xu, Chenjie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7259933/
https://www.ncbi.nlm.nih.gov/pubmed/32523993
http://dx.doi.org/10.1126/sciadv.aaz6919
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author Lio, Daniel Chin Shiuan
Chia, Rui Ning
Kwek, Milton Sheng Yi
Wiraja, Christian
Madden, Leigh Edward
Chang, Hao
Khadir, S. Mohideen Abdul
Wang, Xiaomeng
Becker, David L.
Xu, Chenjie
author_facet Lio, Daniel Chin Shiuan
Chia, Rui Ning
Kwek, Milton Sheng Yi
Wiraja, Christian
Madden, Leigh Edward
Chang, Hao
Khadir, S. Mohideen Abdul
Wang, Xiaomeng
Becker, David L.
Xu, Chenjie
author_sort Lio, Daniel Chin Shiuan
collection PubMed
description Transdermal drug delivery uses chemical, physical, or biochemical enhancers to cross the skin barrier. However, existing platforms require high doses of chemical enhancers or sophisticated equipment, use fragile biomolecules, or are limited to a certain type of drug. Here, we report an innovative methodology based on temporal pressure to enhance the penetration of all kinds of drugs, from small molecules to proteins and nanoparticles (up to 500 nm). The creation of micropores (~3 μm(2)) on the epidermal layer through a temporal pressure treatment results in the elevated expression of gap junctions, and reduced expression of occludin tight junctions. A 1 min treatment of 0.28-MPa allows nanoparticles (up to 500 nm) and macromolecules (up to 20 kDa) to reach a depth of 430-μm into the dermal layer. Using, as an example, the delivery of insulin through topical application after the pressure treatment yields up to 80% drop in blood glucose in diabetic mice.
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spelling pubmed-72599332020-06-09 Temporal pressure enhanced topical drug delivery through micropore formation Lio, Daniel Chin Shiuan Chia, Rui Ning Kwek, Milton Sheng Yi Wiraja, Christian Madden, Leigh Edward Chang, Hao Khadir, S. Mohideen Abdul Wang, Xiaomeng Becker, David L. Xu, Chenjie Sci Adv Research Articles Transdermal drug delivery uses chemical, physical, or biochemical enhancers to cross the skin barrier. However, existing platforms require high doses of chemical enhancers or sophisticated equipment, use fragile biomolecules, or are limited to a certain type of drug. Here, we report an innovative methodology based on temporal pressure to enhance the penetration of all kinds of drugs, from small molecules to proteins and nanoparticles (up to 500 nm). The creation of micropores (~3 μm(2)) on the epidermal layer through a temporal pressure treatment results in the elevated expression of gap junctions, and reduced expression of occludin tight junctions. A 1 min treatment of 0.28-MPa allows nanoparticles (up to 500 nm) and macromolecules (up to 20 kDa) to reach a depth of 430-μm into the dermal layer. Using, as an example, the delivery of insulin through topical application after the pressure treatment yields up to 80% drop in blood glucose in diabetic mice. American Association for the Advancement of Science 2020-05-29 /pmc/articles/PMC7259933/ /pubmed/32523993 http://dx.doi.org/10.1126/sciadv.aaz6919 Text en Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). http://creativecommons.org/licenses/by-nc/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license (http://creativecommons.org/licenses/by-nc/4.0/) , which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited.
spellingShingle Research Articles
Lio, Daniel Chin Shiuan
Chia, Rui Ning
Kwek, Milton Sheng Yi
Wiraja, Christian
Madden, Leigh Edward
Chang, Hao
Khadir, S. Mohideen Abdul
Wang, Xiaomeng
Becker, David L.
Xu, Chenjie
Temporal pressure enhanced topical drug delivery through micropore formation
title Temporal pressure enhanced topical drug delivery through micropore formation
title_full Temporal pressure enhanced topical drug delivery through micropore formation
title_fullStr Temporal pressure enhanced topical drug delivery through micropore formation
title_full_unstemmed Temporal pressure enhanced topical drug delivery through micropore formation
title_short Temporal pressure enhanced topical drug delivery through micropore formation
title_sort temporal pressure enhanced topical drug delivery through micropore formation
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7259933/
https://www.ncbi.nlm.nih.gov/pubmed/32523993
http://dx.doi.org/10.1126/sciadv.aaz6919
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