Mre11 exonuclease activity removes the chain-terminating nucleoside analog gemcitabine from the nascent strand during DNA replication

The Mre11 nuclease is involved in early responses to DNA damage, often mediated by its role in DNA end processing. MRE11 mutations and aberrant expression are associated with carcinogenesis and cancer treatment outcomes. While, in recent years, progress has been made in understanding the role of Mre...

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Detalles Bibliográficos
Autores principales: Boeckemeier, L., Kraehenbuehl, R., Keszthelyi, A., Gasasira, M. U., Vernon, E. G., Beardmore, R., Vågbø, C. B., Chaplin, D., Gollins, S., Krokan, H. E., Lambert, S. A. E., Paizs, B., Hartsuiker, E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7259961/
https://www.ncbi.nlm.nih.gov/pubmed/32523988
http://dx.doi.org/10.1126/sciadv.aaz4126

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