Oncoprotein SND1 hijacks nascent MHC-I heavy chain to ER-associated degradation, leading to impaired CD8(+) T cell response in tumor

SND1 is highly expressed in various cancers. Here, we identify oncoprotein SND1 as a previously unidentified endoplasmic reticulum (ER) membrane–associated protein. The amino-terminal peptide of SND1 predominantly associates with SEC61A, which anchors on ER membrane. The SN domain of SND1 catches an...

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Detalles Bibliográficos
Autores principales: Wang, Yuan, Wang, Xinting, Cui, Xiaoteng, Zhuo, Yue, Li, Hongshuai, Ha, Chuanbo, Xin, Lingbiao, Ren, Yuanyuan, Zhang, Wei, Sun, Xiaoming, Ge, Lin, Liu, Xin, He, Jinyan, Zhang, Tao, Zhang, Kai, Yao, Zhi, Yang, Xi, Yang, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7259962/
https://www.ncbi.nlm.nih.gov/pubmed/32917674
http://dx.doi.org/10.1126/sciadv.aba5412

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