Predicting the viability of beta-lactamase: How folding and binding free energies correlate with beta-lactamase fitness

One of the long-standing holy grails of molecular evolution has been the ability to predict an organism’s fitness directly from its genotype. With such predictive abilities in hand, researchers would be able to more accurately forecast how organisms will evolve and how proteins with novel functions...

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Detalles Bibliográficos
Autores principales: Yang, Jordan, Naik, Nandita, Patel, Jagdish Suresh, Wylie, Christopher S., Gu, Wenze, Huang, Jessie, Ytreberg, F. Marty, Naik, Mandar T., Weinreich, Daniel M., Rubenstein, Brenda M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7259980/
https://www.ncbi.nlm.nih.gov/pubmed/32470971
http://dx.doi.org/10.1371/journal.pone.0233509

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7259980/
https://www.ncbi.nlm.nih.gov/pubmed/32470971
http://dx.doi.org/10.1371/journal.pone.0233509

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