Both d- and l-Glucose Polyphosphates Mimic d-myo-Inositol 1,4,5-Trisphosphate: New Synthetic Agonists and Partial Agonists at the Ins(1,4,5)P(3) Receptor

[Image: see text] Chiral sugar derivatives are potential cyclitol surrogates of the Ca(2+)-mobilizing intracellular messenger d-myo-inositol 1,4,5-trisphosphate [Ins(1,4,5)P(3)]. Six novel polyphosphorylated analogues derived from both d- and l-glucose were synthesized. Binding to Ins(1,4,5)P(3) rec...

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Detalles Bibliográficos
Autores principales: Shipton, Megan L., Riley, Andrew M., Rossi, Ana M., Brearley, Charles A., Taylor, Colin W., Potter, Barry V. L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260056/
https://www.ncbi.nlm.nih.gov/pubmed/32286062
http://dx.doi.org/10.1021/acs.jmedchem.0c00215

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