Comparison of gene disruption induced by cytosine base editing‐mediated iSTOP with CRISPR/Cas9‐mediated frameshift

OBJECTIVES: Recently developed CRISPR‐dependent cytosine base editor (CBE), converting four codons (CAA, CAG, CGA and TGG) into stop codons without DNA double‐strand breaks (DSB), serves as an efficient gene disruption strategy besides uncontrollable CRISPR‐mediated frameshift. However, the detailed...

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Detalles Bibliográficos
Autores principales: Dang, Lu, Li, Guanglei, Wang, Xinjie, Huang, Shisheng, Zhang, Yu, Miao, Yuanxin, Zeng, Lisi, Cui, Shuzhong, Huang, Xingxu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260061/
https://www.ncbi.nlm.nih.gov/pubmed/32350961
http://dx.doi.org/10.1111/cpr.12820

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