Cargando…

Hes1 deficiency causes hematopoietic stem cell exhaustion

The transcriptional repressor Hairy Enhancer of Split 1 (HES1) plays an essential role in the development of many organs by promoting the maintenance of stem/progenitor cells, controlling the reversibility of cellular quiescence, and regulating both cell fate decisions. Deletion of Hes1 in mice resu...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ma, Zhilin, Xu, Jian, Wu, Limei, Wang, Junjie, Lin, Qiqi, Chowdhury, Fabliha A., Mazumder, Md. Habibul H., Hu, Gangqing, Li, Xue, Du, Wei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley & Sons, Inc. 2020
Materias:	Stem Cell Technology: Epigenetics, Genomics, Proteomics and Metabonomics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260087/ https://www.ncbi.nlm.nih.gov/pubmed/32129527 http://dx.doi.org/10.1002/stem.3169

Ejemplares similares

p53‐TP53‐Induced Glycolysis Regulator Mediated Glycolytic Suppression Attenuates DNA Damage and Genomic Instability in Fanconi Anemia Hematopoietic Stem Cells
por: Li, Xue, et al.
Publicado: (2019)

Combined Characterization of microRNA and mRNA Profiles Delineates Early Differentiation Pathways of CD133(+) and CD34(+) Hematopoietic Stem and Progenitor Cells
por: Bissels, Ute, et al.
Publicado: (2011)

Concise Review: Bone Marrow-Derived Stem/Progenitor Cells in Cutaneous Repair and Regeneration
por: Wu, Yaojiong, et al.
Publicado: (2010)

Histone Deacetylase Inhibition with Valproic Acid Downregulates Osteocalcin Gene Expression in Human Dental Pulp Stem Cells and Osteoblasts: Evidence for HDAC2 Involvement
por: Paino, Francesca, et al.
Publicado: (2014)

Genome‐Wide MicroRNA and Gene Analysis of Mesenchymal Stem Cell Chondrogenesis Identifies an Essential Role and Multiple Targets for miR‐140‐5p
por: Barter, Matt J., et al.
Publicado: (2015)

Constitutive activity of a G protein‐coupled receptor, DRD1, contributes to human cerebral organoid formation
por: Wang, Qinying, et al.
Publicado: (2020)

The epitranscriptome landscape of small noncoding RNAs in stem cells
por: McElhinney, James M.W.R., et al.
Publicado: (2020)

A Reciprocal Role of the Smad4‐Taz Axis in Osteogenesis and Adipogenesis of Mesenchymal Stem Cells
por: Park, Jin Seok, et al.
Publicado: (2018)

Somatic MIWI2 Hinders Direct Lineage Reprogramming From Fibroblast to Hepatocyte
por: Shi, Xiaojie, et al.
Publicado: (2019)

Mitochondrial Phosphoenolpyruvate Carboxykinase Regulates Osteogenic Differentiation by Modulating AMPK/ULK1‐Dependent Autophagy
por: Li, Zheng, et al.
Publicado: (2019)

Genome‐wide CRISPR screen identifies ZIC2 as an essential gene that controls the cell fate of early mesodermal precursors to human heart progenitors
por: Xu, Jiejia, et al.
Publicado: (2020)

Identifying a Lung Stem Cell Subpopulation by Combining Single-Cell Morphometrics, Organoid Culture, and Transcriptomics
por: Fujimura, Takashi, et al.
Publicado: (2023)

Bone Marrow Mesenchymal Stem Cells-Derived miR-21-5p Protects Grafted Islets Against Apoptosis by Targeting PDCD4
por: Wang, Jingwen, et al.
Publicado: (2022)

Mesenchymal Stromal Cell Secretome Is Affected by Tissue Source and Donor Age
por: Turlo, Agnieszka J, et al.
Publicado: (2023)

Gfi-1B Promoter Remains Associated with Active Chromatin Marks Throughout Erythroid Differentiation of Human Primary Progenitor Cells
por: Laurent, Benoît, et al.
Publicado: (2009)

Mesenchymal PGD(2) activates an ILC2-Treg axis to promote proliferation of normal and malignant HSPCs
por: Wu, Limei, et al.
Publicado: (2020)

Hes1 Desynchronizes Differentiation of Pluripotent Cells by Modulating STAT3 Activity
por: Zhou, Xinzhi, et al.
Publicado: (2013)

Differential interactions between Notch and ID factors control neurogenesis by modulating Hes factor autoregulation
por: Boareto, Marcelo, et al.
Publicado: (2017)

Proteomic dataset of wolframin-deficient mouse heart and skeletal muscles
por: Eimre, Margus, et al.
Publicado: (2018)

Role of microvascular endothelial cells on proliferation, migration and adhesion of hematopoietic stem cells
por: Lin, Fanli, et al.
Publicado: (2020)

Gene set control analysis predicts hematopoietic control mechanisms from genome-wide transcription factor binding data
por: Joshi, Anagha, et al.
Publicado: (2013)

Hes4 Controls Proliferative Properties of Neural Stem Cells During Retinal Ontogenesis
por: El Yakoubi, Warif, et al.
Publicado: (2012)

Late fetal hematopoietic failure results from ZBTB11 deficiency despite abundant HSC specification
por: Cao, Huimin, et al.
Publicado: (2023)

Genomotyping of Pseudomonas putida strains using P. putida KT2440-based high-density DNA microarrays: implications for transcriptomics studies
por: Ballerstedt, Hendrik, et al.
Publicado: (2007)

Functional Gene Expression Profiling in Yeast Implicates Translational Dysfunction in Mutant Huntingtin Toxicity
por: Tauber, Eran, et al.
Publicado: (2011)

Proteomic Analysis of Native Hepatocyte Nuclear Factor-4α (HNF4α) Isoforms, Phosphorylation Status, and Interactive Cofactors
por: Daigo, Kenji, et al.
Publicado: (2011)

Microarray and Proteomic Analysis of Breast Cancer Cell and Osteoblast Co-cultures: ROLE OF OSTEOBLAST MATRIX METALLOPROTEINASE (MMP)-13 IN BONE METASTASIS
por: Morrison, Charlotte, et al.
Publicado: (2011)

Biochemical Characterization and N-terminomics Analysis of Leukolysin, the Membrane-type 6 Matrix Metalloprotease (MMP25): CHEMOKINE AND VIMENTIN CLEAVAGES ENHANCE CELL MIGRATION AND MACROPHAGE PHAGOCYTIC ACTIVITIES
por: Starr, Amanda E., et al.
Publicado: (2012)

Molecular Cloning and Characterization of First Organic Matrix Protein from Sclerites of Red Coral, Corallium rubrum
por: Debreuil, Julien, et al.
Publicado: (2012)

Genome-wide Analysis of Transcription Factor E2F1 Mutant Proteins Reveals That N- and C-terminal Protein Interaction Domains Do Not Participate in Targeting E2F1 to the Human Genome
por: Cao, Alina R., et al.
Publicado: (2011)

Dissecting the in Vivo Metabolic Potential of Two Human Gut Acetogens
por: Rey, Federico E., et al.
Publicado: (2010)

Proteomic Characterization of Plasma Membrane-proximal T Cell Activation Responses
por: de Wet, Ben, et al.
Publicado: (2011)

Identification of New Substrates of the Protein-tyrosine Phosphatase PTP1B by Bayesian Integration of Proteome Evidence
por: Ferrari, Emanuela, et al.
Publicado: (2011)

Identification of Anhydrobiosis-related Genes from an Expressed Sequence Tag Database in the Cryptobiotic Midge Polypedilum vanderplanki (Diptera; Chironomidae)
por: Cornette, Richard, et al.
Publicado: (2010)

Novel Ubiquitin-derived High Affinity Binding Proteins with Tumor Targeting Properties
por: Lorey, Susan, et al.
Publicado: (2014)

Proteomic Analysis Reveals Age-related Changes in Tendon Matrix Composition, with Age- and Injury-specific Matrix Fragmentation
por: Peffers, Mandy J., et al.
Publicado: (2014)

Interactome Analyses of Mature γ-Secretase Complexes Reveal Distinct Molecular Environments of Presenilin (PS) Paralogs and Preferential Binding of Signal Peptide Peptidase to PS2
por: Jeon, Amy Hye Won, et al.
Publicado: (2013)

Mass Spectrometry Imaging and Identification of Peptides Associated with Cephalic Ganglia Regeneration in Schmidtea mediterranea
por: Ong, Ta-Hsuan, et al.
Publicado: (2016)

Identification and Pharmacological Inactivation of the MYCN Gene Network as a Therapeutic Strategy for Neuroblastic Tumor Cells
por: Chayka, Olesya, et al.
Publicado: (2015)

Discovery Proteomics Identifies a Molecular Link between the Coatomer Protein Complex I and Androgen Receptor-dependent Transcription
por: Hsiao, Jordy J., et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_e5uq73l9v75m90d4bfu53g3ds0