Combination of CHEK1/2 Inhibition and Ionizing Radiation Results in Abscopal Tumor Response through Increased Micronuclei Formation

We explore a novel strategy of activating immune signaling through increased micronuclei formation utilizing a cell cycle checkpoint inhibitor to drive cell cycle progression following ionizing radiation. The Chk1/2 inhibitor AZD7762 is used to abrogate radiation therapy (RT)-induced G2/M cell cycle...

Descripción completa

Detalles Bibliográficos
Autores principales: Chao, Hann-Hsiang, Karagounis, Ilias V., Thomas, Christoforos, François, Noëlle B., Facciabene, Andrea, Koumenis, Constantinos, Maity, Amit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260113/
https://www.ncbi.nlm.nih.gov/pubmed/32335582
http://dx.doi.org/10.1038/s41388-020-1300-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260113/
https://www.ncbi.nlm.nih.gov/pubmed/32335582
http://dx.doi.org/10.1038/s41388-020-1300-x

Ejemplares similares