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TAK1 regulates the tumor microenvironment through inflammatory, angiogenetic and apoptotic signaling cascades

Transforming growth factor beta-activated kinase 1 (TAK1) has been implicated for its role in inflammatory signaling and as an important mediator of cellular apoptosis and necroptosis in various cell types. Our recent discovery of a first-in-class, potent and selective TAK1 inhibitor, takinib, repre...

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Detalles Bibliográficos
Autores principales:	Scarneo, Scott A., Yang, Kelly W., Roques, Jose R., Dai, Alanna, Eibschutz, Liesl S., Hughes, Philip, Haystead, Timothy A.J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2020
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260121/ https://www.ncbi.nlm.nih.gov/pubmed/32523651 http://dx.doi.org/10.18632/oncotarget.27606

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