Analysis of the microbial species, antimicrobial sensitivity and drug resistance in 2652 patients of nursing hospital

OBJECTIVE: To understand the microbial species, antimicrobial sensitivity and drug resistance of patients in the nursing hospital, to bring clinical guiding significance to the use of antimicrobial in the nursing hospital. METHODS: A retrospective analysis of bacterial and drug sensitivity report of 2652 patients in nursing hospitals. RESULTS: There were 2652 cases of bacterial and drug sensitivity results, including 1202 positive cases, 652 females accounted for 54.24%, and 550 males accounted for 45.76%, concentrated in 70–99 years old. There were 57 kinds of bacteria, 303 cases of Gram-positive bacteria accounted for 25.21%, 808 cases of Gram-negative bacteria accounted for 67.22%, and fungi accounted for 7.57%. The positive samples were mainly from urine (35.94%) and sputum (48.59%). The main Gram-positive bacteria in the positive samples were Staphylococcus aureus (53.14%), Enterococcus faecalis (12.87%), Staphylococcus epidermidis (10.23%), Staphylococcus haemolyticus (6.93%), Enterococcus faecium (3.96%). The main Gram-negative bacteria in the positive samples were E. coli (35.27%), Pseudomonas aeruginosa (20.67%), Klebsiella pneumoniae (13.99%), Proteus mirabilis (8.66%), Bowman The main fungi in the positive samples of the bacillus (5.57%) were Candida albicans (59.34%), Candida albicans (16.48%), and Candida glabrata (14.29%). Among the Gram-positive bacteria, Enterococcus faecium and Enterococcus faecalis are easily detected in urine. Staphylococcus haemolyticus and Staphylococcus epidermidis are easily detected in sputum. Staphylococcus aureus is easily detected in sputum and secretions. Among the Gram-negative bacteria, E. coli and Klebsiella pneumoniae are easily detected in sputum and urine. Proteus mirabilis is easily detected in the urine. Pseudomonas aeruginosa and Acinetobacter baumannii are easily detected in sputum. Among the fungi, Candida albicans, Candida bulgaricus, and Candida glabrata are easily detected in sputum. There is a significant statistically difference in the distribution of P. aeruginosa in all age groups. The resistance rate of Staphylococcus aureus to levofloxacin and penicillin are above 90%, the resistance rate to clindamycin and erythromycin are above 80%, the resistance rate to gentamicin is above 70%, and vancomycin and linezolid The sensitivity rate of amine is 100.0%, the sensitivity rate to rifampicin and teicoplanin are above 90%, and the sensitivity to compound sulfamethoxazole and streptomycin are above 80%. Staphylococcus aureus resistant to vancomycin and linezolid are not found this time. The resistance rate of E. coli to compound sulfamethoxazole is above 60%, the resistance rate to cefuroxime, ceftriaxone, levofloxacin, and ciprofloxacin are above 70%, and the resistance rate to cefazolin is above 80%. The resistance rate to ampicillin is above 90%, the sensitivity rate to nitrofurantoin, minocycline and cefoxitin are above 60%, and the sensitivity to cefoperazone sulbactam and piperacillin tazobactam is above 70%. The sensitivity rate of ropamine, imipenem and amikacin are above 80%. The resistance rate of Proteus mirabilis to nitrofurantoin is 100%, the resistance rate to ampicillin are above 90%, and the resistance rate to compound sulfamethoxazole, levofloxacin and ciprofloxacin are above 80%. For cefazolin and gentamicin The rate of resistance is above 70%. The sensitivity rate to cefoxitin, imipenem and amikacin are above 80%, and the sensitivity to meropenem, cefoperazone sulbactam, and piperacillin tazobactam are above 90%. Klebsiella pneumoniae to cefazolin, gentamicin, ampicillin, cefuroxime, ceftazidime, cefoxitin, ceftriaxone, ampicillin sulbactam, compound sulfamethoxazole, levofloxacin, ciprofloxacin The drug resistance rate is above 60%, the sensitivity rate to amikacin is only above 60%, and the sensitivity rate to imipenem and meropenem is only above 50%. Pseudomonas aeruginosa tested resistance to antimicrobial is below 50%, sensitivity to ceftazidime, cefepime, meropenem, imipenem, amikacin are above 60%, sensitivity to polymyxin B is above 90%, the sensitivity rate of tigecycline is 100%. The resistance rate of Candida glabrata to fluorocytosine is above 60%, the sensitivity rate to amphotericin B, fluconazole and itraconazole are above 60%, and the sensitivity rate of voriconazole is above 90%. CONCLUSION: There is a difference between this data and the bacteria data in Shanghai. It is necessary to understand the bacteria sensitivity rate and resistance rate of antimicrobial in the nursing hospital, and it has certain guiding significance for the clinical of the nursing hospital.