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Two nights of recovery sleep restores hippocampal connectivity but not episodic memory after total sleep deprivation
Sleep deprivation significantly impairs a range of cognitive and brain function, particularly episodic memory and the underlying hippocampal function. However, it remains controversial whether one or two nights of recovery sleep following sleep deprivation fully restores brain and cognitive function...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260173/ https://www.ncbi.nlm.nih.gov/pubmed/32472075 http://dx.doi.org/10.1038/s41598-020-65086-x |
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author | Chai, Ya Fang, Zhuo Yang, Fan Nils Xu, Sihua Deng, Yao Raine, Andrew Wang, Jieqiong Yu, Meichen Basner, Mathias Goel, Namni Kim, Junghoon J. Wolk, David A. Detre, John A. Dinges, David F. Rao, Hengyi |
author_facet | Chai, Ya Fang, Zhuo Yang, Fan Nils Xu, Sihua Deng, Yao Raine, Andrew Wang, Jieqiong Yu, Meichen Basner, Mathias Goel, Namni Kim, Junghoon J. Wolk, David A. Detre, John A. Dinges, David F. Rao, Hengyi |
author_sort | Chai, Ya |
collection | PubMed |
description | Sleep deprivation significantly impairs a range of cognitive and brain function, particularly episodic memory and the underlying hippocampal function. However, it remains controversial whether one or two nights of recovery sleep following sleep deprivation fully restores brain and cognitive function. In this study, we used functional magnetic resonance imaging (fMRI) and examined the effects of two consecutive nights (20-hour time-in-bed) of recovery sleep on resting-state hippocampal connectivity and episodic memory deficits following one night of total sleep deprivation (TSD) in 39 healthy adults in a controlled in-laboratory protocol. TSD significantly reduced memory performance in a scene recognition task, impaired hippocampal connectivity to multiple prefrontal and default mode network regions, and disrupted the relationships between memory performance and hippocampal connectivity. Following TSD, two nights of recovery sleep restored hippocampal connectivity to baseline levels, but did not fully restore memory performance nor its associations with hippocampal connectivity. These findings suggest that more than two nights of recovery sleep are needed to fully restore memory function and hippocampal-memory associations after one night of total sleep loss. |
format | Online Article Text |
id | pubmed-7260173 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-72601732020-06-05 Two nights of recovery sleep restores hippocampal connectivity but not episodic memory after total sleep deprivation Chai, Ya Fang, Zhuo Yang, Fan Nils Xu, Sihua Deng, Yao Raine, Andrew Wang, Jieqiong Yu, Meichen Basner, Mathias Goel, Namni Kim, Junghoon J. Wolk, David A. Detre, John A. Dinges, David F. Rao, Hengyi Sci Rep Article Sleep deprivation significantly impairs a range of cognitive and brain function, particularly episodic memory and the underlying hippocampal function. However, it remains controversial whether one or two nights of recovery sleep following sleep deprivation fully restores brain and cognitive function. In this study, we used functional magnetic resonance imaging (fMRI) and examined the effects of two consecutive nights (20-hour time-in-bed) of recovery sleep on resting-state hippocampal connectivity and episodic memory deficits following one night of total sleep deprivation (TSD) in 39 healthy adults in a controlled in-laboratory protocol. TSD significantly reduced memory performance in a scene recognition task, impaired hippocampal connectivity to multiple prefrontal and default mode network regions, and disrupted the relationships between memory performance and hippocampal connectivity. Following TSD, two nights of recovery sleep restored hippocampal connectivity to baseline levels, but did not fully restore memory performance nor its associations with hippocampal connectivity. These findings suggest that more than two nights of recovery sleep are needed to fully restore memory function and hippocampal-memory associations after one night of total sleep loss. Nature Publishing Group UK 2020-05-29 /pmc/articles/PMC7260173/ /pubmed/32472075 http://dx.doi.org/10.1038/s41598-020-65086-x Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Chai, Ya Fang, Zhuo Yang, Fan Nils Xu, Sihua Deng, Yao Raine, Andrew Wang, Jieqiong Yu, Meichen Basner, Mathias Goel, Namni Kim, Junghoon J. Wolk, David A. Detre, John A. Dinges, David F. Rao, Hengyi Two nights of recovery sleep restores hippocampal connectivity but not episodic memory after total sleep deprivation |
title | Two nights of recovery sleep restores hippocampal connectivity but not episodic memory after total sleep deprivation |
title_full | Two nights of recovery sleep restores hippocampal connectivity but not episodic memory after total sleep deprivation |
title_fullStr | Two nights of recovery sleep restores hippocampal connectivity but not episodic memory after total sleep deprivation |
title_full_unstemmed | Two nights of recovery sleep restores hippocampal connectivity but not episodic memory after total sleep deprivation |
title_short | Two nights of recovery sleep restores hippocampal connectivity but not episodic memory after total sleep deprivation |
title_sort | two nights of recovery sleep restores hippocampal connectivity but not episodic memory after total sleep deprivation |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260173/ https://www.ncbi.nlm.nih.gov/pubmed/32472075 http://dx.doi.org/10.1038/s41598-020-65086-x |
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