TRPV4 disrupts mitochondrial transport and causes axonal degeneration via a CaMKII-dependent elevation of intracellular Ca(2+)

The cation channel transient receptor potential vanilloid 4 (TRPV4) is one of the few identified ion channels that can directly cause inherited neurodegeneration syndromes, but the molecular mechanisms are unknown. Here, we show that in vivo expression of a neuropathy-causing TRPV4 mutant (TRPV4(R26...

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Detalles Bibliográficos
Autores principales: Woolums, Brian M., McCray, Brett A., Sung, Hyun, Tabuchi, Masashi, Sullivan, Jeremy M., Ruppell, Kendra Takle, Yang, Yunpeng, Mamah, Catherine, Aisenberg, William H., Saavedra-Rivera, Pamela C., Larin, Bryan S., Lau, Alexander R., Robinson, Douglas N., Xiang, Yang, Wu, Mark N., Sumner, Charlotte J., Lloyd, Thomas E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260201/
https://www.ncbi.nlm.nih.gov/pubmed/32471994
http://dx.doi.org/10.1038/s41467-020-16411-5

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