A genome-scale map of DNA methylation turnover identifies site-specific dependencies of DNMT and TET activity

DNA methylation is considered a stable epigenetic mark, yet methylation patterns can vary during differentiation and in diseases such as cancer. Local levels of DNA methylation result from opposing enzymatic activities, the rates of which remain largely unknown. Here we developed a theoretical and e...

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Detalles Bibliográficos
Autores principales: Ginno, Paul Adrian, Gaidatzis, Dimos, Feldmann, Angelika, Hoerner, Leslie, Imanci, Dilek, Burger, Lukas, Zilbermann, Frederic, Peters, Antoine H. F. M., Edenhofer, Frank, Smallwood, Sébastien A., Krebs, Arnaud R., Schübeler, Dirk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260214/
https://www.ncbi.nlm.nih.gov/pubmed/32471981
http://dx.doi.org/10.1038/s41467-020-16354-x

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