Cargando…

Kefir peptides alleviate high-fat diet-induced atherosclerosis by attenuating macrophage accumulation and oxidative stress in ApoE knockout mice

In the past decade, the high morbidity and mortality of atherosclerotic disease have been prevalent worldwide. High-fat food consumption has been suggested to be an overarching factor for atherosclerosis incidence. This study aims to investigate the effects of kefir peptides on high-fat diet (HFD)-i...

Descripción completa

Detalles Bibliográficos
Autores principales: Tung, Min-Che, Lan, Ying-Wei, Li, Hsin-Han, Chen, Hsiao-Ling, Chen, Sheng-Yi, Chen, Yu-Hsuan, Lin, Chi-Chien, Tu, Min-Yu, Chen, Chuan-Mu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260220/
https://www.ncbi.nlm.nih.gov/pubmed/32472055
http://dx.doi.org/10.1038/s41598-020-65782-8
_version_ 1783540271724625920
author Tung, Min-Che
Lan, Ying-Wei
Li, Hsin-Han
Chen, Hsiao-Ling
Chen, Sheng-Yi
Chen, Yu-Hsuan
Lin, Chi-Chien
Tu, Min-Yu
Chen, Chuan-Mu
author_facet Tung, Min-Che
Lan, Ying-Wei
Li, Hsin-Han
Chen, Hsiao-Ling
Chen, Sheng-Yi
Chen, Yu-Hsuan
Lin, Chi-Chien
Tu, Min-Yu
Chen, Chuan-Mu
author_sort Tung, Min-Che
collection PubMed
description In the past decade, the high morbidity and mortality of atherosclerotic disease have been prevalent worldwide. High-fat food consumption has been suggested to be an overarching factor for atherosclerosis incidence. This study aims to investigate the effects of kefir peptides on high-fat diet (HFD)-induced atherosclerosis in apolipoprotein E knockout (ApoE(−/−)) mice. 7-week old male ApoE(−/−) and normal C57BL/6 mice were randomly divided into five groups (n = 8). Atherosclerotic lesion development in ApoE(−/−) mice was established after fed the HFD for 12 weeks compared to standard chow diet (SCD)-fed C57BL/6 and ApoE(−/−) control groups. Kefir peptides oral administration significantly improved atherosclerotic lesion development by protecting against endothelial dysfunction, decreasing oxidative stress, reducing aortic lipid deposition, attenuating macrophage accumulation, and suppressing the inflammatory immune response compared with the HFD/ApoE(−/−) mock group. Moreover, the high dose of kefir peptides substantially inhibited aortic fibrosis and restored the fibrosis in the aorta root close to that observed in the C57BL/6 normal control group. Our findings show, for the first time, anti-atherosclerotic progression via kefir peptides consumption in HFD-fed ApoE(−/−) mice. The profitable effects of kefir peptides provide new perspectives for its use as an anti-atherosclerotic agent in the preventive medicine.
format Online
Article
Text
id pubmed-7260220
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-72602202020-06-05 Kefir peptides alleviate high-fat diet-induced atherosclerosis by attenuating macrophage accumulation and oxidative stress in ApoE knockout mice Tung, Min-Che Lan, Ying-Wei Li, Hsin-Han Chen, Hsiao-Ling Chen, Sheng-Yi Chen, Yu-Hsuan Lin, Chi-Chien Tu, Min-Yu Chen, Chuan-Mu Sci Rep Article In the past decade, the high morbidity and mortality of atherosclerotic disease have been prevalent worldwide. High-fat food consumption has been suggested to be an overarching factor for atherosclerosis incidence. This study aims to investigate the effects of kefir peptides on high-fat diet (HFD)-induced atherosclerosis in apolipoprotein E knockout (ApoE(−/−)) mice. 7-week old male ApoE(−/−) and normal C57BL/6 mice were randomly divided into five groups (n = 8). Atherosclerotic lesion development in ApoE(−/−) mice was established after fed the HFD for 12 weeks compared to standard chow diet (SCD)-fed C57BL/6 and ApoE(−/−) control groups. Kefir peptides oral administration significantly improved atherosclerotic lesion development by protecting against endothelial dysfunction, decreasing oxidative stress, reducing aortic lipid deposition, attenuating macrophage accumulation, and suppressing the inflammatory immune response compared with the HFD/ApoE(−/−) mock group. Moreover, the high dose of kefir peptides substantially inhibited aortic fibrosis and restored the fibrosis in the aorta root close to that observed in the C57BL/6 normal control group. Our findings show, for the first time, anti-atherosclerotic progression via kefir peptides consumption in HFD-fed ApoE(−/−) mice. The profitable effects of kefir peptides provide new perspectives for its use as an anti-atherosclerotic agent in the preventive medicine. Nature Publishing Group UK 2020-05-29 /pmc/articles/PMC7260220/ /pubmed/32472055 http://dx.doi.org/10.1038/s41598-020-65782-8 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Tung, Min-Che
Lan, Ying-Wei
Li, Hsin-Han
Chen, Hsiao-Ling
Chen, Sheng-Yi
Chen, Yu-Hsuan
Lin, Chi-Chien
Tu, Min-Yu
Chen, Chuan-Mu
Kefir peptides alleviate high-fat diet-induced atherosclerosis by attenuating macrophage accumulation and oxidative stress in ApoE knockout mice
title Kefir peptides alleviate high-fat diet-induced atherosclerosis by attenuating macrophage accumulation and oxidative stress in ApoE knockout mice
title_full Kefir peptides alleviate high-fat diet-induced atherosclerosis by attenuating macrophage accumulation and oxidative stress in ApoE knockout mice
title_fullStr Kefir peptides alleviate high-fat diet-induced atherosclerosis by attenuating macrophage accumulation and oxidative stress in ApoE knockout mice
title_full_unstemmed Kefir peptides alleviate high-fat diet-induced atherosclerosis by attenuating macrophage accumulation and oxidative stress in ApoE knockout mice
title_short Kefir peptides alleviate high-fat diet-induced atherosclerosis by attenuating macrophage accumulation and oxidative stress in ApoE knockout mice
title_sort kefir peptides alleviate high-fat diet-induced atherosclerosis by attenuating macrophage accumulation and oxidative stress in apoe knockout mice
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260220/
https://www.ncbi.nlm.nih.gov/pubmed/32472055
http://dx.doi.org/10.1038/s41598-020-65782-8
work_keys_str_mv AT tungminche kefirpeptidesalleviatehighfatdietinducedatherosclerosisbyattenuatingmacrophageaccumulationandoxidativestressinapoeknockoutmice
AT lanyingwei kefirpeptidesalleviatehighfatdietinducedatherosclerosisbyattenuatingmacrophageaccumulationandoxidativestressinapoeknockoutmice
AT lihsinhan kefirpeptidesalleviatehighfatdietinducedatherosclerosisbyattenuatingmacrophageaccumulationandoxidativestressinapoeknockoutmice
AT chenhsiaoling kefirpeptidesalleviatehighfatdietinducedatherosclerosisbyattenuatingmacrophageaccumulationandoxidativestressinapoeknockoutmice
AT chenshengyi kefirpeptidesalleviatehighfatdietinducedatherosclerosisbyattenuatingmacrophageaccumulationandoxidativestressinapoeknockoutmice
AT chenyuhsuan kefirpeptidesalleviatehighfatdietinducedatherosclerosisbyattenuatingmacrophageaccumulationandoxidativestressinapoeknockoutmice
AT linchichien kefirpeptidesalleviatehighfatdietinducedatherosclerosisbyattenuatingmacrophageaccumulationandoxidativestressinapoeknockoutmice
AT tuminyu kefirpeptidesalleviatehighfatdietinducedatherosclerosisbyattenuatingmacrophageaccumulationandoxidativestressinapoeknockoutmice
AT chenchuanmu kefirpeptidesalleviatehighfatdietinducedatherosclerosisbyattenuatingmacrophageaccumulationandoxidativestressinapoeknockoutmice