Lipid Nanoparticle Formulation Increases Efficiency of DNA-Vectored Vaccines/Immunoprophylaxis in Animals Including Transchromosomic Bovines

The use of nucleic acid as a drug substance for vaccines and other gene-based medicines continues to evolve. Here, we have used a technology originally developed for mRNA in vivo delivery to enhance the immunogenicity of DNA vaccines. We demonstrate that neutralizing antibodies produced in rabbits a...

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Detalles Bibliográficos
Autores principales: Mucker, Eric M., Karmali, Priya P., Vega, Jerel, Kwilas, Steven A., Wu, Hua, Joselyn, Matthew, Ballantyne, John, Sampey, Darryl, Mukthavaram, Rajesh, Sullivan, Eddie, Chivukula, Pad, Hooper, Jay W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260227/
https://www.ncbi.nlm.nih.gov/pubmed/32472093
http://dx.doi.org/10.1038/s41598-020-65059-0

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