ISG15 and ISGylation is required for pancreatic cancer stem cell mitophagy and metabolic plasticity

Pancreatic cancer stem cells (PaCSCs) drive pancreatic cancer tumorigenesis, chemoresistance and metastasis. While eliminating this subpopulation of cells would theoretically result in tumor eradication, PaCSCs are extremely plastic and can successfully adapt to targeted therapies. In this study, we...

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Detalles Bibliográficos
Autores principales: Alcalá, Sonia, Sancho, Patricia, Martinelli, Paola, Navarro, Diego, Pedrero, Coral, Martín-Hijano, Laura, Valle, Sandra, Earl, Julie, Rodríguez-Serrano, Macarena, Ruiz-Cañas, Laura, Rojas, Katerin, Carrato, Alfredo, García-Bermejo, Laura, Fernández-Moreno, Miguel Ángel, Hermann, Patrick C., Sainz, Bruno
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260233/
https://www.ncbi.nlm.nih.gov/pubmed/32472071
http://dx.doi.org/10.1038/s41467-020-16395-2

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