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CYP17A1 deficient XY mice display susceptibility to atherosclerosis, altered lipidomic profile and atypical sex development

CYP17A1 is a cytochrome P450 enzyme with 17-alpha-hydroxylase and C17,20-lyase activities. CYP17A1 genetic variants are associated with coronary artery disease, myocardial infarction and visceral and subcutaneous fat distribution; however, the underlying pathological mechanisms remain unknown. We ai...

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Detalles Bibliográficos
Autores principales:	Aherrahrou, Redouane, Kulle, Alexandra E., Alenina, Natalia, Werner, Ralf, Vens-Cappell, Simeon, Bader, Michael, Schunkert, Heribert, Erdmann, Jeanette, Aherrahrou, Zouhair
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260244/ https://www.ncbi.nlm.nih.gov/pubmed/32472014 http://dx.doi.org/10.1038/s41598-020-65601-0

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