Cargando…
Use of static and dynamic [(18)F]-F-DOPA PET parameters for detecting patients with glioma recurrence or progression
BACKGROUND: Static [(18)F]-F-DOPA PET images are currently used for identifying patients with glioma recurrence/progression after treatment, although the additional diagnostic value of dynamic parameters remains unknown in this setting. The aim of this study was to evaluate the performances of stati...
Autores principales: | , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260331/ https://www.ncbi.nlm.nih.gov/pubmed/32472232 http://dx.doi.org/10.1186/s13550-020-00645-x |
_version_ | 1783540291150544896 |
---|---|
author | Zaragori, Timothée Ginet, Merwan Marie, Pierre-Yves Roch, Véronique Grignon, Rachel Gauchotte, Guillaume Rech, Fabien Blonski, Marie Lamiral, Zohra Taillandier, Luc Imbert, Laëtitia Verger, Antoine |
author_facet | Zaragori, Timothée Ginet, Merwan Marie, Pierre-Yves Roch, Véronique Grignon, Rachel Gauchotte, Guillaume Rech, Fabien Blonski, Marie Lamiral, Zohra Taillandier, Luc Imbert, Laëtitia Verger, Antoine |
author_sort | Zaragori, Timothée |
collection | PubMed |
description | BACKGROUND: Static [(18)F]-F-DOPA PET images are currently used for identifying patients with glioma recurrence/progression after treatment, although the additional diagnostic value of dynamic parameters remains unknown in this setting. The aim of this study was to evaluate the performances of static and dynamic [(18)F]-F-DOPA PET parameters for detecting patients with glioma recurrence/progression as well as assess further relationships with patient outcome. METHODS: Fifty-one consecutive patients who underwent an [(18)F]-F-DOPA PET for a suspected glioma recurrence/progression at post-resection MRI, were retrospectively included. Static parameters, including mean and maximum tumor-to-normal-brain (TBR) ratios, tumor-to-striatum (TSR) ratios, and metabolic tumor volume (MTV), as well as dynamic parameters with time-to-peak (TTP) values and curve slope, were tested for predicting the following: (1) glioma recurrence/progression at 6 months after the PET exam and (2) survival on longer follow-up. RESULTS: All static parameters were significant predictors of glioma recurrence/progression (accuracy ≥ 94%) with all parameters also associated with mean progression-free survival (PFS) in the overall population (all p < 0.001, 29.7 vs. 0.4 months for TBR(max), TSR(max), and MTV). The curve slope was the sole dynamic PET predictor of glioma recurrence/progression (accuracy = 76.5%) and was also associated with mean PFS (p < 0.001, 18.0 vs. 0.4 months). However, no additional information was provided relative to static parameters in multivariate analysis. CONCLUSION: Although patients with glioma recurrence/progression can be detected by both static and dynamic [(18)F]-F-DOPA PET parameters, most of this diagnostic information can be achieved by conventional static parameters. |
format | Online Article Text |
id | pubmed-7260331 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-72603312020-06-08 Use of static and dynamic [(18)F]-F-DOPA PET parameters for detecting patients with glioma recurrence or progression Zaragori, Timothée Ginet, Merwan Marie, Pierre-Yves Roch, Véronique Grignon, Rachel Gauchotte, Guillaume Rech, Fabien Blonski, Marie Lamiral, Zohra Taillandier, Luc Imbert, Laëtitia Verger, Antoine EJNMMI Res Original Research BACKGROUND: Static [(18)F]-F-DOPA PET images are currently used for identifying patients with glioma recurrence/progression after treatment, although the additional diagnostic value of dynamic parameters remains unknown in this setting. The aim of this study was to evaluate the performances of static and dynamic [(18)F]-F-DOPA PET parameters for detecting patients with glioma recurrence/progression as well as assess further relationships with patient outcome. METHODS: Fifty-one consecutive patients who underwent an [(18)F]-F-DOPA PET for a suspected glioma recurrence/progression at post-resection MRI, were retrospectively included. Static parameters, including mean and maximum tumor-to-normal-brain (TBR) ratios, tumor-to-striatum (TSR) ratios, and metabolic tumor volume (MTV), as well as dynamic parameters with time-to-peak (TTP) values and curve slope, were tested for predicting the following: (1) glioma recurrence/progression at 6 months after the PET exam and (2) survival on longer follow-up. RESULTS: All static parameters were significant predictors of glioma recurrence/progression (accuracy ≥ 94%) with all parameters also associated with mean progression-free survival (PFS) in the overall population (all p < 0.001, 29.7 vs. 0.4 months for TBR(max), TSR(max), and MTV). The curve slope was the sole dynamic PET predictor of glioma recurrence/progression (accuracy = 76.5%) and was also associated with mean PFS (p < 0.001, 18.0 vs. 0.4 months). However, no additional information was provided relative to static parameters in multivariate analysis. CONCLUSION: Although patients with glioma recurrence/progression can be detected by both static and dynamic [(18)F]-F-DOPA PET parameters, most of this diagnostic information can be achieved by conventional static parameters. Springer Berlin Heidelberg 2020-05-29 /pmc/articles/PMC7260331/ /pubmed/32472232 http://dx.doi.org/10.1186/s13550-020-00645-x Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Original Research Zaragori, Timothée Ginet, Merwan Marie, Pierre-Yves Roch, Véronique Grignon, Rachel Gauchotte, Guillaume Rech, Fabien Blonski, Marie Lamiral, Zohra Taillandier, Luc Imbert, Laëtitia Verger, Antoine Use of static and dynamic [(18)F]-F-DOPA PET parameters for detecting patients with glioma recurrence or progression |
title | Use of static and dynamic [(18)F]-F-DOPA PET parameters for detecting patients with glioma recurrence or progression |
title_full | Use of static and dynamic [(18)F]-F-DOPA PET parameters for detecting patients with glioma recurrence or progression |
title_fullStr | Use of static and dynamic [(18)F]-F-DOPA PET parameters for detecting patients with glioma recurrence or progression |
title_full_unstemmed | Use of static and dynamic [(18)F]-F-DOPA PET parameters for detecting patients with glioma recurrence or progression |
title_short | Use of static and dynamic [(18)F]-F-DOPA PET parameters for detecting patients with glioma recurrence or progression |
title_sort | use of static and dynamic [(18)f]-f-dopa pet parameters for detecting patients with glioma recurrence or progression |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260331/ https://www.ncbi.nlm.nih.gov/pubmed/32472232 http://dx.doi.org/10.1186/s13550-020-00645-x |
work_keys_str_mv | AT zaragoritimothee useofstaticanddynamic18ffdopapetparametersfordetectingpatientswithgliomarecurrenceorprogression AT ginetmerwan useofstaticanddynamic18ffdopapetparametersfordetectingpatientswithgliomarecurrenceorprogression AT mariepierreyves useofstaticanddynamic18ffdopapetparametersfordetectingpatientswithgliomarecurrenceorprogression AT rochveronique useofstaticanddynamic18ffdopapetparametersfordetectingpatientswithgliomarecurrenceorprogression AT grignonrachel useofstaticanddynamic18ffdopapetparametersfordetectingpatientswithgliomarecurrenceorprogression AT gauchotteguillaume useofstaticanddynamic18ffdopapetparametersfordetectingpatientswithgliomarecurrenceorprogression AT rechfabien useofstaticanddynamic18ffdopapetparametersfordetectingpatientswithgliomarecurrenceorprogression AT blonskimarie useofstaticanddynamic18ffdopapetparametersfordetectingpatientswithgliomarecurrenceorprogression AT lamiralzohra useofstaticanddynamic18ffdopapetparametersfordetectingpatientswithgliomarecurrenceorprogression AT taillandierluc useofstaticanddynamic18ffdopapetparametersfordetectingpatientswithgliomarecurrenceorprogression AT imbertlaetitia useofstaticanddynamic18ffdopapetparametersfordetectingpatientswithgliomarecurrenceorprogression AT vergerantoine useofstaticanddynamic18ffdopapetparametersfordetectingpatientswithgliomarecurrenceorprogression |