Pulmonary delivery of nanostructured lipid carriers for effective repurposing of salinomycin as an antiviral agent

Coronavirus disease outbreak caused a severe public health burden all over the world. Salinomycin (SAL) is a broad-spectrum antibiotic that had drawn attention in selective targeting of cancer and viral infections. Recent drug screen identified SAL as a potent antiviral agent against SARS-CoV-2. In...

Descripción completa

Detalles Bibliográficos
Autores principales: Pindiprolu, Sai Kiran S.S., Kumar, Chirravuri S. Phani, Kumar Golla, Venu Sampath, P., Likitha, K., Shreyas Chandra, S.K., Esub Basha, R.K., Ramachandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260485/
https://www.ncbi.nlm.nih.gov/pubmed/32516655
http://dx.doi.org/10.1016/j.mehy.2020.109858
_version_ 1783540324160765952
author Pindiprolu, Sai Kiran S.S.
Kumar, Chirravuri S. Phani
Kumar Golla, Venu Sampath
P., Likitha
K., Shreyas Chandra
S.K., Esub Basha
R.K., Ramachandra
author_facet Pindiprolu, Sai Kiran S.S.
Kumar, Chirravuri S. Phani
Kumar Golla, Venu Sampath
P., Likitha
K., Shreyas Chandra
S.K., Esub Basha
R.K., Ramachandra
author_sort Pindiprolu, Sai Kiran S.S.
collection PubMed
description Coronavirus disease outbreak caused a severe public health burden all over the world. Salinomycin (SAL) is a broad-spectrum antibiotic that had drawn attention in selective targeting of cancer and viral infections. Recent drug screen identified SAL as a potent antiviral agent against SARS-CoV-2. In this hypothesis, we discuss the potential of pulmonary delivery of SAL using nanostructured lipid carriers (NLCs) against SARS-CoV-2.
format Online
Article
Text
id pubmed-7260485
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Elsevier Ltd.
record_format MEDLINE/PubMed
spelling pubmed-72604852020-06-01 Pulmonary delivery of nanostructured lipid carriers for effective repurposing of salinomycin as an antiviral agent Pindiprolu, Sai Kiran S.S. Kumar, Chirravuri S. Phani Kumar Golla, Venu Sampath P., Likitha K., Shreyas Chandra S.K., Esub Basha R.K., Ramachandra Med Hypotheses Article Coronavirus disease outbreak caused a severe public health burden all over the world. Salinomycin (SAL) is a broad-spectrum antibiotic that had drawn attention in selective targeting of cancer and viral infections. Recent drug screen identified SAL as a potent antiviral agent against SARS-CoV-2. In this hypothesis, we discuss the potential of pulmonary delivery of SAL using nanostructured lipid carriers (NLCs) against SARS-CoV-2. Elsevier Ltd. 2020-10 2020-05-30 /pmc/articles/PMC7260485/ /pubmed/32516655 http://dx.doi.org/10.1016/j.mehy.2020.109858 Text en © 2020 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Pindiprolu, Sai Kiran S.S.
Kumar, Chirravuri S. Phani
Kumar Golla, Venu Sampath
P., Likitha
K., Shreyas Chandra
S.K., Esub Basha
R.K., Ramachandra
Pulmonary delivery of nanostructured lipid carriers for effective repurposing of salinomycin as an antiviral agent
title Pulmonary delivery of nanostructured lipid carriers for effective repurposing of salinomycin as an antiviral agent
title_full Pulmonary delivery of nanostructured lipid carriers for effective repurposing of salinomycin as an antiviral agent
title_fullStr Pulmonary delivery of nanostructured lipid carriers for effective repurposing of salinomycin as an antiviral agent
title_full_unstemmed Pulmonary delivery of nanostructured lipid carriers for effective repurposing of salinomycin as an antiviral agent
title_short Pulmonary delivery of nanostructured lipid carriers for effective repurposing of salinomycin as an antiviral agent
title_sort pulmonary delivery of nanostructured lipid carriers for effective repurposing of salinomycin as an antiviral agent
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260485/
https://www.ncbi.nlm.nih.gov/pubmed/32516655
http://dx.doi.org/10.1016/j.mehy.2020.109858
work_keys_str_mv AT pindiprolusaikiranss pulmonarydeliveryofnanostructuredlipidcarriersforeffectiverepurposingofsalinomycinasanantiviralagent
AT kumarchirravurisphani pulmonarydeliveryofnanostructuredlipidcarriersforeffectiverepurposingofsalinomycinasanantiviralagent
AT kumargollavenusampath pulmonarydeliveryofnanostructuredlipidcarriersforeffectiverepurposingofsalinomycinasanantiviralagent
AT plikitha pulmonarydeliveryofnanostructuredlipidcarriersforeffectiverepurposingofsalinomycinasanantiviralagent
AT kshreyaschandra pulmonarydeliveryofnanostructuredlipidcarriersforeffectiverepurposingofsalinomycinasanantiviralagent
AT skesubbasha pulmonarydeliveryofnanostructuredlipidcarriersforeffectiverepurposingofsalinomycinasanantiviralagent
AT rkramachandra pulmonarydeliveryofnanostructuredlipidcarriersforeffectiverepurposingofsalinomycinasanantiviralagent

Ejemplares similares