Cargando…

A Triple Combination of Metformin, Acetylsalicylic Acid, and Oseltamivir Phosphate Impacts Tumour Spheroid Viability and Upends Chemoresistance in Triple-Negative Breast Cancer

INTRODUCTION: Targeted multimodal approaches need to be strategically developed to control tumour growth and prevent metastatic burden successfully. Breast cancer presents a unique clinical problem because of the variety of cellular subtypes that arise. The tumour stage and cellular subtypes often d...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sambi, Manpreet, Samuel, Vanessa, Qorri, Bessi, Haq, Sabah, Burov, Sergey V, Markvicheva, Elena, Harless, William, Szewczuk, Myron R
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2020
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260544/ https://www.ncbi.nlm.nih.gov/pubmed/32546966 http://dx.doi.org/10.2147/DDDT.S242514

Ejemplares similares

Repositioning of Old Drugs for Novel Cancer Therapies: Continuous Therapeutic Perfusion of Aspirin and Oseltamivir Phosphate with Gemcitabine Treatment Disables Tumor Progression, Chemoresistance, and Metastases
por: Qorri, Bessi, et al.
Publicado: (2022)

Alternative therapies for metastatic breast cancer: multimodal approach targeting tumor cell heterogeneity
por: Sambi, Manpreet, et al.
Publicado: (2017)

Next Generation of Cancer Drug Repurposing: Therapeutic Combination of Aspirin and Oseltamivir Phosphate Potentiates Gemcitabine to Disable Key Survival Pathways Critical for Pancreatic Cancer Progression
por: Qorri, Bessi, et al.
Publicado: (2022)

Novel Molecular Mechanism of Aspirin and Celecoxib Targeting Mammalian Neuraminidase-1 Impedes Epidermal Growth Factor Receptor Signaling Axis and Induces Apoptosis in Pancreatic Cancer Cells
por: Qorri, Bessi, et al.
Publicado: (2020)

Functionalized Folic Acid-Conjugated Amphiphilic Alternating Copolymer Actively Targets 3D Multicellular Tumour Spheroids and Delivers the Hydrophobic Drug to the Inner Core
por: Li, Xia, et al.
Publicado: (2018)

3D Multicellular Stem-Like Human Breast Tumor Spheroids Enhance Tumorigenicity of Orthotopic Xenografts in Athymic Nude Rat Model
por: Mokhtari, Reza Bayat, et al.
Publicado: (2021)

Sialylation transmogrifies human breast and pancreatic cancer cells into 3D multicellular tumor spheroids using cyclic RGD-peptide induced self-assembly
por: Akasov, Roman, et al.
Publicado: (2016)

Novel Therapeutic Target Critical for SARS-CoV-2 Infectivity and Induction of the Cytokine Release Syndrome
por: Harless, William W., et al.
Publicado: (2023)

Therapeutic potential of medicinal marijuana: an educational primer for health care professionals
por: Mouhamed, Yara, et al.
Publicado: (2018)

Impact of Fucosylation on Self-Assembly of Prostate and Breast Tumor Spheroids by Using Cyclo-RGDfK(TPP) Peptide and Image Object Detection
por: Kalaydina, Regina-Veronicka, et al.
Publicado: (2019)

The Biased G-Protein-Coupled Receptor Agonism Bridges the Gap between the Insulin Receptor and the Metabolic Syndrome
por: Liauchonak, Iryna, et al.
Publicado: (2018)

Sialylation facilitates self-assembly of 3D multicellular prostaspheres by using cyclo-RGDfK(TPP) peptide
por: Haq, Sabah, et al.
Publicado: (2017)

The crucial role of primary care providers in the long-term follow-up of adult survivors of childhood cancer
por: Jain, Justin, et al.
Publicado: (2019)

The Next-Generation of Combination Cancer Immunotherapy: Epigenetic Immunomodulators Transmogrify Immune Training to Enhance Immunotherapy
por: Mokhtari, Reza Bayat, et al.
Publicado: (2021)

Oseltamivir phosphate monotherapy ablates tumor neovascularization, growth, and metastasis in mouse model of human triple-negative breast adenocarcinoma
por: Haxho, Fiona, et al.
Publicado: (2014)

Current Challenges in Cancer Immunotherapy: Multimodal Approaches to Improve Efficacy and Patient Response Rates
por: Sambi, Manpreet, et al.
Publicado: (2019)

Galileo upended science
Publicado: (2009)

Non-Nutritive Sweeteners and Their Implications on the Development of Metabolic Syndrome
por: Liauchonak, Iryna, et al.
Publicado: (2019)

Recent advances in “smart” delivery systems for extended drug release in cancer therapy
por: Kalaydina, Regina-Veronicka, et al.
Publicado: (2018)

Therapeutic targeting of Neu1 sialidase with oseltamivir phosphate (Tamiflu®) disables cancer cell survival in human pancreatic cancer with acquired chemoresistance
por: O’Shea, Leah K, et al.
Publicado: (2014)

Agonist-Biased Signaling via Matrix Metalloproteinase-9 Promotes Extracellular Matrix Remodeling
por: Qorri, Bessi, et al.
Publicado: (2018)

Next-Generation Multimodality of Nanomedicine Therapy: Size and Structure Dependence of Folic Acid Conjugated Copolymers Actively Target Cancer Cells in Disabling Cell Division and Inducing Apoptosis
por: Sambi, Manpreet, et al.
Publicado: (2019)

Multicellular tumor spheroids in microcapsules as a novel 3D in vitro model in tumor biology
por: Markvicheva, Elena, et al.
Publicado: (2013)

How Galileo's spy glass upended science
Publicado: (2009)

How Galileo’s spy glass upended science
Publicado: (2009)

Low-carbon energy in the Gulf: Upending the rentier state?
por: Sim, Li-Chen
Publicado: (2020)

Paradigm shift How Galileo's spy glass upended science
Publicado: (2009)

Paradigm shift How Galileo's spy glass upended science
Publicado: (2009)

The fate of chemoresistance in triple negative breast cancer (TNBC)
por: O’Reilly, Elma A., et al.
Publicado: (2015)

Oseltamivir phosphate released from injectable Pickering emulsions over an extended term disables human pancreatic cancer cell survival
por: Wood, Kurt, et al.
Publicado: (2018)

Paradigm shift How Galileo's first spy glass upended science
Publicado: (2009)

Pharmacokinetics and Pharmacodynamics of Conventional-Dose vs Triple-Dose Oseltamivir in Severely Immunocompromised Children With Influenza
por: Bautista, Francisco, et al.
Publicado: (2019)

Novel strategies to target chemoresistant triple-negative breast cancer
por: Venkatesh, Jaganathan, et al.
Publicado: (2020)

DSTYK Enhances Chemoresistance in Triple-Negative Breast Cancer Cells
por: Ogbu, Stella C., et al.
Publicado: (2021)

Role of ABCB1 in mediating chemoresistance of triple-negative breast cancers
por: Abd El-Aziz, Yomna S., et al.
Publicado: (2021)

The Hippo Pathway Effectors YAP/TAZ-TEAD Oncoproteins as Emerging Therapeutic Targets in the Tumor Microenvironment
por: Mokhtari, Reza Bayat, et al.
Publicado: (2023)

Combinatorial and sequential delivery of gemcitabine and oseltamivir phosphate from implantable poly(d,l-lactic-co-glycolic acid) cylinders disables human pancreatic cancer cell survival
por: Allison Logan, Stephanie, et al.
Publicado: (2017)

Triple Combination of Amantadine, Ribavirin, and Oseltamivir Is Highly Active and Synergistic against Drug Resistant Influenza Virus Strains In Vitro
por: Nguyen, Jack T., et al.
Publicado: (2010)

Characterization of Triple-Negative Breast Cancer MDA-MB-231 Cell Spheroid Model
por: Huang, Zhaoming, et al.
Publicado: (2020)

The Turnaway Study: A Case of Self-Correction in Science Upended by Political Motivation and Unvetted Findings
por: Coleman, Priscilla K.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_4niop9qr7ldsrco41e5u10e50h