Functional and structural insights into the MRX/MRN complex, a key player in recognition and repair of DNA double-strand breaks

Chromosomal DNA double-strand breaks (DSBs) are potentially lethal DNA lesions that pose a significant threat to genome stability and therefore need to be repaired to preserve genome integrity. Eukaryotic cells possess two main mechanisms for repairing DSBs: non-homologous end-joining (NHEJ) and hom...

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Detalles Bibliográficos
Autores principales: Tisi, Renata, Vertemara, Jacopo, Zampella, Giuseppe, Longhese, Maria Pia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2020
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260605/
https://www.ncbi.nlm.nih.gov/pubmed/32489527
http://dx.doi.org/10.1016/j.csbj.2020.05.013

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