Multi-route antifungal administration in the management of urinary Candida glabrata bezoar

A 65-year-old lady was admitted with urosepsis and imaging suggesting right sided hydronephrosis secondary to a filling defect consistent with a fungal bezoar. An indwelling urinary catheter and a right percutaneous nephrostomy tube were inserted. Candida glabrata cultured from urine was resistant t...

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Autores principales: Viswambaram, Pravin, Misko, Jeanie, Rawlins, Matthew, Clark, Sarah, Dyer, John, Hayne, Dickon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Inflammation and Infection
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260667/
https://www.ncbi.nlm.nih.gov/pubmed/32489899
http://dx.doi.org/10.1016/j.eucr.2020.101275
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author Viswambaram, Pravin
Misko, Jeanie
Rawlins, Matthew
Clark, Sarah
Dyer, John
Hayne, Dickon
author_facet Viswambaram, Pravin
Misko, Jeanie
Rawlins, Matthew
Clark, Sarah
Dyer, John
Hayne, Dickon
author_sort Viswambaram, Pravin
collection PubMed
description A 65-year-old lady was admitted with urosepsis and imaging suggesting right sided hydronephrosis secondary to a filling defect consistent with a fungal bezoar. An indwelling urinary catheter and a right percutaneous nephrostomy tube were inserted. Candida glabrata cultured from urine was resistant to fluconazole. Amphotericin B was instilled into the renal pelvis via the nephrostomy tube while intravenous liposomal amphotericin was administered daily along with oral flucytosine. This multi-modal antifungal administration was continued for 14 days. Clinical and biochemical improvement was achieved and repeat imaging showed complete resolution of the filling defects and hydronephrosis.
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spelling pubmed-72606672020-06-01 Multi-route antifungal administration in the management of urinary Candida glabrata bezoar Viswambaram, Pravin Misko, Jeanie Rawlins, Matthew Clark, Sarah Dyer, John Hayne, Dickon Urol Case Rep Inflammation and Infection A 65-year-old lady was admitted with urosepsis and imaging suggesting right sided hydronephrosis secondary to a filling defect consistent with a fungal bezoar. An indwelling urinary catheter and a right percutaneous nephrostomy tube were inserted. Candida glabrata cultured from urine was resistant to fluconazole. Amphotericin B was instilled into the renal pelvis via the nephrostomy tube while intravenous liposomal amphotericin was administered daily along with oral flucytosine. This multi-modal antifungal administration was continued for 14 days. Clinical and biochemical improvement was achieved and repeat imaging showed complete resolution of the filling defects and hydronephrosis. Elsevier 2020-05-23 /pmc/articles/PMC7260667/ /pubmed/32489899 http://dx.doi.org/10.1016/j.eucr.2020.101275 Text en © 2020 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Inflammation and Infection
Viswambaram, Pravin
Misko, Jeanie
Rawlins, Matthew
Clark, Sarah
Dyer, John
Hayne, Dickon
Multi-route antifungal administration in the management of urinary Candida glabrata bezoar
title Multi-route antifungal administration in the management of urinary Candida glabrata bezoar
title_full Multi-route antifungal administration in the management of urinary Candida glabrata bezoar
title_fullStr Multi-route antifungal administration in the management of urinary Candida glabrata bezoar
title_full_unstemmed Multi-route antifungal administration in the management of urinary Candida glabrata bezoar
title_short Multi-route antifungal administration in the management of urinary Candida glabrata bezoar
title_sort multi-route antifungal administration in the management of urinary candida glabrata bezoar
topic Inflammation and Infection
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260667/
https://www.ncbi.nlm.nih.gov/pubmed/32489899
http://dx.doi.org/10.1016/j.eucr.2020.101275
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