Human islets contain a subpopulation of glucagon-like peptide-1 secreting α cells that is increased in type 2 diabetes

OBJECTIVES: Our study shows that glucagon-like peptide-1 (GLP-1) is secreted within human islets and may play an unexpectedly important paracrine role in islet physiology and pathophysiology. It is known that α cells within rodent and human pancreatic islets are capable of secreting GLP-1, but littl...

Descripción completa

Detalles Bibliográficos
Autores principales: Campbell, Scott A., Golec, Dominic P., Hubert, Matt, Johnson, Janyne, Salamon, Nicole, Barr, Amy, MacDonald, Patrick E., Philippaert, Koenraad, Light, Peter E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260680/
https://www.ncbi.nlm.nih.gov/pubmed/32413586
http://dx.doi.org/10.1016/j.molmet.2020.101014

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260680/
https://www.ncbi.nlm.nih.gov/pubmed/32413586
http://dx.doi.org/10.1016/j.molmet.2020.101014

Ejemplares similares