Insight into norcantharidin, a small-molecule synthetic compound with potential multi-target anticancer activities

Norcantharidin (NCTD) is a demethylated derivative of cantharidin, which is an anticancer active ingredient of traditional Chinese medicine, and is currently used clinically as a routine anti-cancer drug in China. Clarifying the anticancer effect and molecular mechanism of NCTD is critical for its c...

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Autores principales: Pan, Mu-Su, Cao, Jin, Fan, Yue-Zu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260769/
https://www.ncbi.nlm.nih.gov/pubmed/32514288
http://dx.doi.org/10.1186/s13020-020-00338-6
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author Pan, Mu-Su
Cao, Jin
Fan, Yue-Zu
author_facet Pan, Mu-Su
Cao, Jin
Fan, Yue-Zu
author_sort Pan, Mu-Su
collection PubMed
description Norcantharidin (NCTD) is a demethylated derivative of cantharidin, which is an anticancer active ingredient of traditional Chinese medicine, and is currently used clinically as a routine anti-cancer drug in China. Clarifying the anticancer effect and molecular mechanism of NCTD is critical for its clinical application. Here, we summarized the physiological, chemical, pharmacokinetic characteristics and clinical applications of NCTD. Besides, we mainly focus on its potential multi-target anticancer activities and underlying mechanisms, and discuss the problems existing in clinical application and scientific research of NCTD, so as to provide a potential anticancer therapeutic agent for human malignant tumors.
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spelling pubmed-72607692020-06-07 Insight into norcantharidin, a small-molecule synthetic compound with potential multi-target anticancer activities Pan, Mu-Su Cao, Jin Fan, Yue-Zu Chin Med Review Norcantharidin (NCTD) is a demethylated derivative of cantharidin, which is an anticancer active ingredient of traditional Chinese medicine, and is currently used clinically as a routine anti-cancer drug in China. Clarifying the anticancer effect and molecular mechanism of NCTD is critical for its clinical application. Here, we summarized the physiological, chemical, pharmacokinetic characteristics and clinical applications of NCTD. Besides, we mainly focus on its potential multi-target anticancer activities and underlying mechanisms, and discuss the problems existing in clinical application and scientific research of NCTD, so as to provide a potential anticancer therapeutic agent for human malignant tumors. BioMed Central 2020-05-29 /pmc/articles/PMC7260769/ /pubmed/32514288 http://dx.doi.org/10.1186/s13020-020-00338-6 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Pan, Mu-Su
Cao, Jin
Fan, Yue-Zu
Insight into norcantharidin, a small-molecule synthetic compound with potential multi-target anticancer activities
title Insight into norcantharidin, a small-molecule synthetic compound with potential multi-target anticancer activities
title_full Insight into norcantharidin, a small-molecule synthetic compound with potential multi-target anticancer activities
title_fullStr Insight into norcantharidin, a small-molecule synthetic compound with potential multi-target anticancer activities
title_full_unstemmed Insight into norcantharidin, a small-molecule synthetic compound with potential multi-target anticancer activities
title_short Insight into norcantharidin, a small-molecule synthetic compound with potential multi-target anticancer activities
title_sort insight into norcantharidin, a small-molecule synthetic compound with potential multi-target anticancer activities
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260769/
https://www.ncbi.nlm.nih.gov/pubmed/32514288
http://dx.doi.org/10.1186/s13020-020-00338-6
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