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Ultrastructural evidence for self-replication of Alzheimer-associated Aβ42 amyloid along the sides of fibrils

The nucleation of Alzheimer-associated Aβ peptide monomers can be catalyzed by preexisting Aβ fibrils. This leads to autocatalytic amplification of aggregate mass and underlies self-replication and generation of toxic oligomers associated with several neurodegenerative diseases. However, the nature...

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Detalles Bibliográficos
Autores principales:	Törnquist, Mattias, Cukalevski, Risto, Weininger, Ulrich, Meisl, Georg, Knowles, Tuomas P. J., Leiding, Thom, Malmendal, Anders, Akke, Mikael, Linse, Sara
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2020
Materias:	Physical Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260961/ https://www.ncbi.nlm.nih.gov/pubmed/32439711 http://dx.doi.org/10.1073/pnas.1918481117

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