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Determinants of Brachial-Ankle Pulse Wave Velocity and Vascular Aging in Healthy Older Subjects
BACKGROUND: Vascular aging is characterized by increasing arterial stiffness as measured by pulse wave velocity. The present study evaluated the factors influencing vascular aging in Chinese healthy older subjects. MATERIAL/METHODS: Disease- and treatment-free aged (≥60 years) participants were recr...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Scientific Literature, Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260998/ https://www.ncbi.nlm.nih.gov/pubmed/32445331 http://dx.doi.org/10.12659/MSM.923112 |
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author | Sang, Yu Wu, Xiaofen Miao, Jianping Cao, Ming Ruan, Lei Zhang, Cuntai |
author_facet | Sang, Yu Wu, Xiaofen Miao, Jianping Cao, Ming Ruan, Lei Zhang, Cuntai |
author_sort | Sang, Yu |
collection | PubMed |
description | BACKGROUND: Vascular aging is characterized by increasing arterial stiffness as measured by pulse wave velocity. The present study evaluated the factors influencing vascular aging in Chinese healthy older subjects. MATERIAL/METHODS: Disease- and treatment-free aged (≥60 years) participants were recruited from 2014 to 2019. Cardiometabolic risk factors and brachial-ankle pulse wave velocity (baPWV) were assessed. We defined healthy vascular aging (HVA) as the lowest 10% and early vascular aging (EVA) as the highest 10% of the baPWV distribution, after adjustment for age and blood pressure (BP). We fitted linear and logistic regression models to assess the determinants. RESULTS: In all, 794 subjects (mean age 66.5±6.8 years, 71.0% male) were recruited; the 10(th) and 90(th) percentiles of baPWV were 1278 cm/s and 1955 cm/s, respectively. Age, BP, heart rate, and triglycerides were all positively associated with baPWV, whereas male subjects and body mass index (BMI) were negatively associated with baPWV. The number of participants diagnosed with either HVA or EVA was 80. Logistic regression models showed that sex, BMI, heart rate, and triglycerides were associated with HVA and EVA after adjustment for age, BP, and other confounding factors. CONCLUSIONS: Male, high BMI, low heart rate, and low triglycerides are protective factors for vascular aging in the healthy aged population. Management of BMI, heart rate, triglycerides in a reasonable range may help to alleviate the vascular aging process. |
format | Online Article Text |
id | pubmed-7260998 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | International Scientific Literature, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-72609982020-06-01 Determinants of Brachial-Ankle Pulse Wave Velocity and Vascular Aging in Healthy Older Subjects Sang, Yu Wu, Xiaofen Miao, Jianping Cao, Ming Ruan, Lei Zhang, Cuntai Med Sci Monit Clinical Research BACKGROUND: Vascular aging is characterized by increasing arterial stiffness as measured by pulse wave velocity. The present study evaluated the factors influencing vascular aging in Chinese healthy older subjects. MATERIAL/METHODS: Disease- and treatment-free aged (≥60 years) participants were recruited from 2014 to 2019. Cardiometabolic risk factors and brachial-ankle pulse wave velocity (baPWV) were assessed. We defined healthy vascular aging (HVA) as the lowest 10% and early vascular aging (EVA) as the highest 10% of the baPWV distribution, after adjustment for age and blood pressure (BP). We fitted linear and logistic regression models to assess the determinants. RESULTS: In all, 794 subjects (mean age 66.5±6.8 years, 71.0% male) were recruited; the 10(th) and 90(th) percentiles of baPWV were 1278 cm/s and 1955 cm/s, respectively. Age, BP, heart rate, and triglycerides were all positively associated with baPWV, whereas male subjects and body mass index (BMI) were negatively associated with baPWV. The number of participants diagnosed with either HVA or EVA was 80. Logistic regression models showed that sex, BMI, heart rate, and triglycerides were associated with HVA and EVA after adjustment for age, BP, and other confounding factors. CONCLUSIONS: Male, high BMI, low heart rate, and low triglycerides are protective factors for vascular aging in the healthy aged population. Management of BMI, heart rate, triglycerides in a reasonable range may help to alleviate the vascular aging process. International Scientific Literature, Inc. 2020-05-23 /pmc/articles/PMC7260998/ /pubmed/32445331 http://dx.doi.org/10.12659/MSM.923112 Text en © Med Sci Monit, 2020 This work is licensed under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) ) |
spellingShingle | Clinical Research Sang, Yu Wu, Xiaofen Miao, Jianping Cao, Ming Ruan, Lei Zhang, Cuntai Determinants of Brachial-Ankle Pulse Wave Velocity and Vascular Aging in Healthy Older Subjects |
title | Determinants of Brachial-Ankle Pulse Wave Velocity and Vascular Aging in Healthy Older Subjects |
title_full | Determinants of Brachial-Ankle Pulse Wave Velocity and Vascular Aging in Healthy Older Subjects |
title_fullStr | Determinants of Brachial-Ankle Pulse Wave Velocity and Vascular Aging in Healthy Older Subjects |
title_full_unstemmed | Determinants of Brachial-Ankle Pulse Wave Velocity and Vascular Aging in Healthy Older Subjects |
title_short | Determinants of Brachial-Ankle Pulse Wave Velocity and Vascular Aging in Healthy Older Subjects |
title_sort | determinants of brachial-ankle pulse wave velocity and vascular aging in healthy older subjects |
topic | Clinical Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260998/ https://www.ncbi.nlm.nih.gov/pubmed/32445331 http://dx.doi.org/10.12659/MSM.923112 |
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