Hepatic gap junctions amplify alcohol liver injury by propagating cGAS-mediated IRF3 activation

Alcohol-related liver disease (ALD) accounts for the majority of cirrhosis and liver-related deaths worldwide. Activation of IFN-regulatory factor (IRF3) initiates alcohol-induced hepatocyte apoptosis, which fuels a robust secondary inflammatory response that drives ALD. The dominant molecular mecha...

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Detalles Bibliográficos
Autores principales: Luther, Jay, Khan, Sanjoy, Gala, Manish K., Kedrin, Dmitriy, Sridharan, Gautham, Goodman, Russell P., Garber, John J., Masia, Ricard, Diagacomo, Erik, Adams, Daniel, King, Kevin R., Piaker, Samuel, Reinecker, Hans-Christian, Yarmush, Martin L., Argemi, Josepmaria, Bataller, Ramon, Dienstag, Jules L., Chung, Raymond T., Patel, Suraj J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7261084/
https://www.ncbi.nlm.nih.gov/pubmed/32393626
http://dx.doi.org/10.1073/pnas.1911870117

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