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The internal region of CtIP negatively regulates DNA end resection

DNA double-strand breaks are repaired by end-joining or homologous recombination. A key-committing step of recombination is DNA end resection. In resection, phosphorylated CtIP first promotes the endonuclease of MRE11–RAD50–NBS1 (MRN). Subsequently, CtIP also stimulates the WRN/BLM–DNA2 pathway, coo...

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Detalles Bibliográficos
Autores principales:	Howard, Sean Michael, Ceppi, Ilaria, Anand, Roopesh, Geiger, Roger, Cejka, Petr
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2020
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7261161/ https://www.ncbi.nlm.nih.gov/pubmed/32347940 http://dx.doi.org/10.1093/nar/gkaa273

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