Emergence of a novel immune-evasion strategy from an ancestral protein fold in bacteriophage Mu

The broad host range bacteriophage Mu employs a novel ‘methylcarbamoyl’ modification to protect its DNA from diverse restriction systems of its hosts. The DNA modification is catalyzed by a phage-encoded protein Mom, whose mechanism of action is a mystery. Here, we characterized the co-factor and me...

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Detalles Bibliográficos
Autores principales: Karambelkar, Shweta, Udupa, Shubha, Gowthami, Vykuntham Naga, Ramachandra, Sharmila Giliyaru, Swapna, Ganduri, Nagaraja, Valakunja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Chemical Biology and Nucleic Acid Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7261163/
https://www.ncbi.nlm.nih.gov/pubmed/32369169
http://dx.doi.org/10.1093/nar/gkaa319

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7261163/
https://www.ncbi.nlm.nih.gov/pubmed/32369169
http://dx.doi.org/10.1093/nar/gkaa319

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