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Structural and functional insights into CWC27/CWC22 heterodimer linking the exon junction complex to spliceosomes

Human CWC27 is an uncharacterized splicing factor and mutations in its gene are linked to retinal degeneration and other developmental defects. We identify the splicing factor CWC22 as the major CWC27 partner. Both CWC27 and CWC22 are present in published B(act) spliceosome structures, but no intera...

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Detalles Bibliográficos
Autores principales:	Busetto, Virginia, Barbosa, Isabelle, Basquin, Jérôme, Marquenet, Émelie, Hocq, Rémi, Hennion, Magali, Paternina, Janio Antonio, Namane, Abdelkader, Conti, Elena, Bensaude, Olivier, Le Hir, Hervé
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2020
Materias:	RNA and RNA-protein complexes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7261170/ https://www.ncbi.nlm.nih.gov/pubmed/32329775 http://dx.doi.org/10.1093/nar/gkaa267

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