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A splice site-sensing conformational switch in U2AF2 is modulated by U2AF1 and its recurrent myelodysplasia-associated mutation

An essential heterodimer of the U2AF1 and U2AF2 pre-mRNA splicing factors nucleates spliceosome assembly at polypyrimidine (Py) signals preceding the major class of 3′ splice sites. U2AF1 frequently acquires an S34F-encoding mutation among patients with myelodysplastic syndromes (MDS). The influence...

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Detalles Bibliográficos
Autores principales:	Warnasooriya, Chandani, Feeney, Callen F, Laird, Kholiswa M, Ermolenko, Dmitri N, Kielkopf, Clara L
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2020
Materias:	RNA and RNA-protein complexes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7261175/ https://www.ncbi.nlm.nih.gov/pubmed/32343311 http://dx.doi.org/10.1093/nar/gkaa293

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