O-GlcNAc regulates gene expression by controlling detained intron splicing

Intron detention in precursor RNAs serves to regulate expression of a substantial fraction of genes in eukaryotic genomes. How detained intron (DI) splicing is controlled is poorly understood. Here, we show that a ubiquitous post-translational modification called O-GlcNAc, which is thought to integr...

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Detalles Bibliográficos
Autores principales: Tan, Zhi-Wei, Fei, George, Paulo, Joao A, Bellaousov, Stanislav, Martin, Sara E S, Duveau, Damien Y, Thomas, Craig J, Gygi, Steven P, Boutz, Paul L, Walker, Suzanne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
RNA and RNA-protein complexes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7261177/
https://www.ncbi.nlm.nih.gov/pubmed/32329777
http://dx.doi.org/10.1093/nar/gkaa263

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