Efficient and risk-reduced genome editing using double nicks enhanced by bacterial recombination factors in multiple species

Site-specific DNA double-strand breaks have been used to generate knock-in through the homology-dependent or -independent pathway. However, low efficiency and accompanying negative impacts such as undesirable indels or tumorigenic potential remain problematic. In this study, we present an enhanced r...

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Detalles Bibliográficos
Autores principales: He, Xiaozhen, Chen, Wenfeng, Liu, Zhen, Yu, Guirong, Chen, Youbang, Cai, Yi-Jun, Sun, Ling, Xu, Wanli, Zhong, Lili, Gao, Caixi, Chen, Jishen, Zhang, Minjie, Yang, Shengxi, Yao, Yizhou, Zhang, Zhiping, Ma, Fujun, Zhang, Chen-Chen, Lu, Hui-Ping, Yu, Bin, Cheng, Tian-Lin, Qiu, Juhui, Sheng, Qing, Zhou, Hai-Meng, Lv, Zhi-Rong, Yan, Junjun, Zhou, Yongjian, Qiu, Zilong, Cui, Zongbin, Zhang, Xi, Meng, Anming, Sun, Qiang, Yang, Yufeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Methods Online
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7261186/
https://www.ncbi.nlm.nih.gov/pubmed/32232370
http://dx.doi.org/10.1093/nar/gkaa195

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