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Temperature controlled high-throughput magnetic tweezers show striking difference in activation energies of replicating viral RNA-dependent RNA polymerases

RNA virus survival depends on efficient viral genome replication, which is performed by the viral RNA dependent RNA polymerase (RdRp). The recent development of high throughput magnetic tweezers has enabled the simultaneous observation of dozens of viral RdRp elongation traces on kilobases long temp...

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Detalles Bibliográficos
Autores principales:	Seifert, Mona, van Nies, Pauline, Papini, Flávia S, Arnold, Jamie J, Poranen, Minna M, Cameron, Craig E, Depken, Martin, Dulin, David
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2020
Materias:	Nucleic Acid Enzymes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7261197/ https://www.ncbi.nlm.nih.gov/pubmed/32286652 http://dx.doi.org/10.1093/nar/gkaa233

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