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The thick waxy coat of mycobacteria, a protective layer against antibiotics and the host's immune system

Tuberculosis, caused by the pathogenic bacterium Mycobacterium tuberculosis (Mtb), is the leading cause of death from an infectious disease, with a mortality rate of over a million people per year. This pathogen's remarkable resilience and infectivity is largely due to its unique waxy cell enve...

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Detalles Bibliográficos
Autores principales: Batt, Sarah M., Minnikin, David E., Besra, Gurdyal S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7261415/
https://www.ncbi.nlm.nih.gov/pubmed/32470138
http://dx.doi.org/10.1042/BCJ20200194
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author Batt, Sarah M.
Minnikin, David E.
Besra, Gurdyal S.
author_facet Batt, Sarah M.
Minnikin, David E.
Besra, Gurdyal S.
author_sort Batt, Sarah M.
collection PubMed
description Tuberculosis, caused by the pathogenic bacterium Mycobacterium tuberculosis (Mtb), is the leading cause of death from an infectious disease, with a mortality rate of over a million people per year. This pathogen's remarkable resilience and infectivity is largely due to its unique waxy cell envelope, 40% of which comprises complex lipids. Therefore, an understanding of the structure and function of the cell wall lipids is of huge indirect clinical significance. This review provides a synopsis of the cell envelope and the major lipids contained within, including structure, biosynthesis and roles in pathogenesis.
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spelling pubmed-72614152020-06-09 The thick waxy coat of mycobacteria, a protective layer against antibiotics and the host's immune system Batt, Sarah M. Minnikin, David E. Besra, Gurdyal S. Biochem J Microbiology Tuberculosis, caused by the pathogenic bacterium Mycobacterium tuberculosis (Mtb), is the leading cause of death from an infectious disease, with a mortality rate of over a million people per year. This pathogen's remarkable resilience and infectivity is largely due to its unique waxy cell envelope, 40% of which comprises complex lipids. Therefore, an understanding of the structure and function of the cell wall lipids is of huge indirect clinical significance. This review provides a synopsis of the cell envelope and the major lipids contained within, including structure, biosynthesis and roles in pathogenesis. Portland Press Ltd. 2020-05-29 2020-05-29 /pmc/articles/PMC7261415/ /pubmed/32470138 http://dx.doi.org/10.1042/BCJ20200194 Text en © 2020 The Author(s) https://creativecommons.org/licenses/by/4.0/ This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) (https://creativecommons.org/licenses/by/4.0/) . Open access for this article was enabled by the participation of University of Birmingham in an all-inclusive Read & Publish pilot with Portland Press and the Biochemical Society under a transformative agreement with JISC.
spellingShingle Microbiology
Batt, Sarah M.
Minnikin, David E.
Besra, Gurdyal S.
The thick waxy coat of mycobacteria, a protective layer against antibiotics and the host's immune system
title The thick waxy coat of mycobacteria, a protective layer against antibiotics and the host's immune system
title_full The thick waxy coat of mycobacteria, a protective layer against antibiotics and the host's immune system
title_fullStr The thick waxy coat of mycobacteria, a protective layer against antibiotics and the host's immune system
title_full_unstemmed The thick waxy coat of mycobacteria, a protective layer against antibiotics and the host's immune system
title_short The thick waxy coat of mycobacteria, a protective layer against antibiotics and the host's immune system
title_sort thick waxy coat of mycobacteria, a protective layer against antibiotics and the host's immune system
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7261415/
https://www.ncbi.nlm.nih.gov/pubmed/32470138
http://dx.doi.org/10.1042/BCJ20200194
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