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Unravelling the myths of R(0) in controlling the dynamics of COVID-19 outbreak: A modelling perspective

COVID-19 is an emerging and rapidly evolving pandemic around the world, which causes severe acute respiratory syndrome and results in substantial morbidity and mortality. To examine the transmission dynamics of COVID-19, we investigate the spread of this pandemic using Malaysia as a case study and s...

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Detalles Bibliográficos
Autores principales: Mohd, Mohd Hafiz, Sulayman, Fatima
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7261458/
https://www.ncbi.nlm.nih.gov/pubmed/32834577
http://dx.doi.org/10.1016/j.chaos.2020.109943
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author Mohd, Mohd Hafiz
Sulayman, Fatima
author_facet Mohd, Mohd Hafiz
Sulayman, Fatima
author_sort Mohd, Mohd Hafiz
collection PubMed
description COVID-19 is an emerging and rapidly evolving pandemic around the world, which causes severe acute respiratory syndrome and results in substantial morbidity and mortality. To examine the transmission dynamics of COVID-19, we investigate the spread of this pandemic using Malaysia as a case study and scrutinise its interactions with some exogenous factors such as limited medical resources and false detection problems. To do this, we employ a simple epidemiological model and analyse this system using modelling and dynamical systems techniques. We discover some contrasting findings with respect to the observations of basic reproduction number: while it is observed that R(0) seems to provide a good description of transmission dynamics in simple outbreak scenarios, this quantity might mislead the assessment on the severity of pandemic when certain complexities such as limited medical resources and false detection problems are incorporated into the model. In particular, we observe the possibility of a COVID-19 outbreak through bistable behaviour, even when the basic reproduction number is less than unity. Based on these findings, we caution policy makers not to make their decisions solely based on the guidance of the basic reproduction number only, which clearly could cause trouble.
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spelling pubmed-72614582020-06-01 Unravelling the myths of R(0) in controlling the dynamics of COVID-19 outbreak: A modelling perspective Mohd, Mohd Hafiz Sulayman, Fatima Chaos Solitons Fractals Article COVID-19 is an emerging and rapidly evolving pandemic around the world, which causes severe acute respiratory syndrome and results in substantial morbidity and mortality. To examine the transmission dynamics of COVID-19, we investigate the spread of this pandemic using Malaysia as a case study and scrutinise its interactions with some exogenous factors such as limited medical resources and false detection problems. To do this, we employ a simple epidemiological model and analyse this system using modelling and dynamical systems techniques. We discover some contrasting findings with respect to the observations of basic reproduction number: while it is observed that R(0) seems to provide a good description of transmission dynamics in simple outbreak scenarios, this quantity might mislead the assessment on the severity of pandemic when certain complexities such as limited medical resources and false detection problems are incorporated into the model. In particular, we observe the possibility of a COVID-19 outbreak through bistable behaviour, even when the basic reproduction number is less than unity. Based on these findings, we caution policy makers not to make their decisions solely based on the guidance of the basic reproduction number only, which clearly could cause trouble. Elsevier Ltd. 2020-09 2020-05-31 /pmc/articles/PMC7261458/ /pubmed/32834577 http://dx.doi.org/10.1016/j.chaos.2020.109943 Text en © 2020 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Mohd, Mohd Hafiz
Sulayman, Fatima
Unravelling the myths of R(0) in controlling the dynamics of COVID-19 outbreak: A modelling perspective
title Unravelling the myths of R(0) in controlling the dynamics of COVID-19 outbreak: A modelling perspective
title_full Unravelling the myths of R(0) in controlling the dynamics of COVID-19 outbreak: A modelling perspective
title_fullStr Unravelling the myths of R(0) in controlling the dynamics of COVID-19 outbreak: A modelling perspective
title_full_unstemmed Unravelling the myths of R(0) in controlling the dynamics of COVID-19 outbreak: A modelling perspective
title_short Unravelling the myths of R(0) in controlling the dynamics of COVID-19 outbreak: A modelling perspective
title_sort unravelling the myths of r(0) in controlling the dynamics of covid-19 outbreak: a modelling perspective
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7261458/
https://www.ncbi.nlm.nih.gov/pubmed/32834577
http://dx.doi.org/10.1016/j.chaos.2020.109943
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