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Morphine induces dysfunction of PINK1/Parkin-mediated mitophagy in spinal cord neurons implying involvement in antinociceptive tolerance

The development of opioid-induced analgesic tolerance is a clinical challenge in long-term use for managing chronic pain. The mechanisms of morphine tolerance are poorly understood. Mitochondria-derived reactive oxygen species (ROS) is a crucial signal inducing analgesic tolerance and pain. Chronic...

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Detalles Bibliográficos
Autores principales:	Kong, Hong, Jiang, Chun-Yi, Hu, Liang, Teng, Peng, Zhang, Yan, Pan, Xiu-Xiu, Sun, Xiao-Di, Liu, Wen-Tao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7261486/ https://www.ncbi.nlm.nih.gov/pubmed/30698724 http://dx.doi.org/10.1093/jmcb/mjz002

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