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Impairment of myocardial perfusion correlates with heart failure severity in patients with non‐compaction cardiomyopathy
AIMS: Non‐compaction cardiomyopathy (NCM) is a congenital heart disease characterized by an arrest of the myocardial compaction process. Although NCM patients have impaired formation of microvasculature, the functional impact of these changes remains undefined. We sought to analyse a potential corre...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7261548/ https://www.ncbi.nlm.nih.gov/pubmed/32212326 http://dx.doi.org/10.1002/ehf2.12631 |
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author | Cerar, Andraz Jaklic, Martina Frljak, Sabina Poglajen, Gregor Zemljic, Gregor Guzic Salobir, Barbara Dolenc Novak, Maja Stalc, Monika Zbacnik, Rok Kozelj, Mirta |
author_facet | Cerar, Andraz Jaklic, Martina Frljak, Sabina Poglajen, Gregor Zemljic, Gregor Guzic Salobir, Barbara Dolenc Novak, Maja Stalc, Monika Zbacnik, Rok Kozelj, Mirta |
author_sort | Cerar, Andraz |
collection | PubMed |
description | AIMS: Non‐compaction cardiomyopathy (NCM) is a congenital heart disease characterized by an arrest of the myocardial compaction process. Although NCM patients have impaired formation of microvasculature, the functional impact of these changes remains undefined. We sought to analyse a potential correlation between myocardial ischemia and heart failure severity in NCM patients. METHODS AND RESULTS: We enrolled 41 NCM patients (28 male and 13 female), aged 21–70 years. In all patients, we have determined left ventricular end‐diastolic volume (LVEDV), left ventricular ejection fraction (LVEF), and global longitudinal strain (GLS) by echocardiography. At the same time, serum levels of N‐terminal pro‐B‐type natriuretic peptide (NT‐proBNP) have been measured, and myocardial single‐photon emission computed tomography at rest and on stress was used to define significant myocardial ischemia defined as summed difference score ≥ 2. Myocardial ischemia has been demonstrated in 11 patients (27%, Group A), and 30 patients showed no significant ischemic changes (73%, Group B). The groups did not differ in sex, age, kidney, or liver function. When compared with Group B, Group A had significantly lower LVEF (35 ± 15% in Group A vs. 53 ± 11% in Group B, P < 0.001), higher LVEDV (188 ± 52 mL vs. 136 ± 52 mL, P = 0.007), lower GLS (−9.9 ± 5.2% vs. −14.5 ± 4.1%, P = 0.001), and higher NT‐proBNP levels (1691 ± 1883 pg/mL vs. 422 ± 877 pg/mL, P = 0.006). Overall, higher summed difference score was associated with lower LVEF (r = −0.48, P = 0.001), higher LVEDV (r = 0.39, P = 0.012), lower GLS (r = 0.352, P = 0.024), and higher levels of NT‐proBNP (r = 0.66, P < 0.001). CONCLUSIONS: The presence of myocardial ischemia in patients with NCM is associated with worse left ventricular function, dilation of the left ventricle, and more pronounced neurohumoral activation. |
format | Online Article Text |
id | pubmed-7261548 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-72615482020-06-01 Impairment of myocardial perfusion correlates with heart failure severity in patients with non‐compaction cardiomyopathy Cerar, Andraz Jaklic, Martina Frljak, Sabina Poglajen, Gregor Zemljic, Gregor Guzic Salobir, Barbara Dolenc Novak, Maja Stalc, Monika Zbacnik, Rok Kozelj, Mirta ESC Heart Fail Original Research Articles AIMS: Non‐compaction cardiomyopathy (NCM) is a congenital heart disease characterized by an arrest of the myocardial compaction process. Although NCM patients have impaired formation of microvasculature, the functional impact of these changes remains undefined. We sought to analyse a potential correlation between myocardial ischemia and heart failure severity in NCM patients. METHODS AND RESULTS: We enrolled 41 NCM patients (28 male and 13 female), aged 21–70 years. In all patients, we have determined left ventricular end‐diastolic volume (LVEDV), left ventricular ejection fraction (LVEF), and global longitudinal strain (GLS) by echocardiography. At the same time, serum levels of N‐terminal pro‐B‐type natriuretic peptide (NT‐proBNP) have been measured, and myocardial single‐photon emission computed tomography at rest and on stress was used to define significant myocardial ischemia defined as summed difference score ≥ 2. Myocardial ischemia has been demonstrated in 11 patients (27%, Group A), and 30 patients showed no significant ischemic changes (73%, Group B). The groups did not differ in sex, age, kidney, or liver function. When compared with Group B, Group A had significantly lower LVEF (35 ± 15% in Group A vs. 53 ± 11% in Group B, P < 0.001), higher LVEDV (188 ± 52 mL vs. 136 ± 52 mL, P = 0.007), lower GLS (−9.9 ± 5.2% vs. −14.5 ± 4.1%, P = 0.001), and higher NT‐proBNP levels (1691 ± 1883 pg/mL vs. 422 ± 877 pg/mL, P = 0.006). Overall, higher summed difference score was associated with lower LVEF (r = −0.48, P = 0.001), higher LVEDV (r = 0.39, P = 0.012), lower GLS (r = 0.352, P = 0.024), and higher levels of NT‐proBNP (r = 0.66, P < 0.001). CONCLUSIONS: The presence of myocardial ischemia in patients with NCM is associated with worse left ventricular function, dilation of the left ventricle, and more pronounced neurohumoral activation. John Wiley and Sons Inc. 2020-03-25 /pmc/articles/PMC7261548/ /pubmed/32212326 http://dx.doi.org/10.1002/ehf2.12631 Text en © 2020 The Authors. ESC Heart Failure published by John Wiley & Sons Ltd on behalf of European Society of Cardiology This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Original Research Articles Cerar, Andraz Jaklic, Martina Frljak, Sabina Poglajen, Gregor Zemljic, Gregor Guzic Salobir, Barbara Dolenc Novak, Maja Stalc, Monika Zbacnik, Rok Kozelj, Mirta Impairment of myocardial perfusion correlates with heart failure severity in patients with non‐compaction cardiomyopathy |
title | Impairment of myocardial perfusion correlates with heart failure severity in patients with non‐compaction cardiomyopathy |
title_full | Impairment of myocardial perfusion correlates with heart failure severity in patients with non‐compaction cardiomyopathy |
title_fullStr | Impairment of myocardial perfusion correlates with heart failure severity in patients with non‐compaction cardiomyopathy |
title_full_unstemmed | Impairment of myocardial perfusion correlates with heart failure severity in patients with non‐compaction cardiomyopathy |
title_short | Impairment of myocardial perfusion correlates with heart failure severity in patients with non‐compaction cardiomyopathy |
title_sort | impairment of myocardial perfusion correlates with heart failure severity in patients with non‐compaction cardiomyopathy |
topic | Original Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7261548/ https://www.ncbi.nlm.nih.gov/pubmed/32212326 http://dx.doi.org/10.1002/ehf2.12631 |
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