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Impairment of myocardial perfusion correlates with heart failure severity in patients with non‐compaction cardiomyopathy

AIMS: Non‐compaction cardiomyopathy (NCM) is a congenital heart disease characterized by an arrest of the myocardial compaction process. Although NCM patients have impaired formation of microvasculature, the functional impact of these changes remains undefined. We sought to analyse a potential corre...

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Autores principales: Cerar, Andraz, Jaklic, Martina, Frljak, Sabina, Poglajen, Gregor, Zemljic, Gregor, Guzic Salobir, Barbara, Dolenc Novak, Maja, Stalc, Monika, Zbacnik, Rok, Kozelj, Mirta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7261548/
https://www.ncbi.nlm.nih.gov/pubmed/32212326
http://dx.doi.org/10.1002/ehf2.12631
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author Cerar, Andraz
Jaklic, Martina
Frljak, Sabina
Poglajen, Gregor
Zemljic, Gregor
Guzic Salobir, Barbara
Dolenc Novak, Maja
Stalc, Monika
Zbacnik, Rok
Kozelj, Mirta
author_facet Cerar, Andraz
Jaklic, Martina
Frljak, Sabina
Poglajen, Gregor
Zemljic, Gregor
Guzic Salobir, Barbara
Dolenc Novak, Maja
Stalc, Monika
Zbacnik, Rok
Kozelj, Mirta
author_sort Cerar, Andraz
collection PubMed
description AIMS: Non‐compaction cardiomyopathy (NCM) is a congenital heart disease characterized by an arrest of the myocardial compaction process. Although NCM patients have impaired formation of microvasculature, the functional impact of these changes remains undefined. We sought to analyse a potential correlation between myocardial ischemia and heart failure severity in NCM patients. METHODS AND RESULTS: We enrolled 41 NCM patients (28 male and 13 female), aged 21–70 years. In all patients, we have determined left ventricular end‐diastolic volume (LVEDV), left ventricular ejection fraction (LVEF), and global longitudinal strain (GLS) by echocardiography. At the same time, serum levels of N‐terminal pro‐B‐type natriuretic peptide (NT‐proBNP) have been measured, and myocardial single‐photon emission computed tomography at rest and on stress was used to define significant myocardial ischemia defined as summed difference score ≥ 2. Myocardial ischemia has been demonstrated in 11 patients (27%, Group A), and 30 patients showed no significant ischemic changes (73%, Group B). The groups did not differ in sex, age, kidney, or liver function. When compared with Group B, Group A had significantly lower LVEF (35 ± 15% in Group A vs. 53 ± 11% in Group B, P < 0.001), higher LVEDV (188 ± 52 mL vs. 136 ± 52 mL, P = 0.007), lower GLS (−9.9 ± 5.2% vs. −14.5 ± 4.1%, P = 0.001), and higher NT‐proBNP levels (1691 ± 1883 pg/mL vs. 422 ± 877 pg/mL, P = 0.006). Overall, higher summed difference score was associated with lower LVEF (r = −0.48, P = 0.001), higher LVEDV (r = 0.39, P = 0.012), lower GLS (r = 0.352, P = 0.024), and higher levels of NT‐proBNP (r = 0.66, P < 0.001). CONCLUSIONS: The presence of myocardial ischemia in patients with NCM is associated with worse left ventricular function, dilation of the left ventricle, and more pronounced neurohumoral activation.
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spelling pubmed-72615482020-06-01 Impairment of myocardial perfusion correlates with heart failure severity in patients with non‐compaction cardiomyopathy Cerar, Andraz Jaklic, Martina Frljak, Sabina Poglajen, Gregor Zemljic, Gregor Guzic Salobir, Barbara Dolenc Novak, Maja Stalc, Monika Zbacnik, Rok Kozelj, Mirta ESC Heart Fail Original Research Articles AIMS: Non‐compaction cardiomyopathy (NCM) is a congenital heart disease characterized by an arrest of the myocardial compaction process. Although NCM patients have impaired formation of microvasculature, the functional impact of these changes remains undefined. We sought to analyse a potential correlation between myocardial ischemia and heart failure severity in NCM patients. METHODS AND RESULTS: We enrolled 41 NCM patients (28 male and 13 female), aged 21–70 years. In all patients, we have determined left ventricular end‐diastolic volume (LVEDV), left ventricular ejection fraction (LVEF), and global longitudinal strain (GLS) by echocardiography. At the same time, serum levels of N‐terminal pro‐B‐type natriuretic peptide (NT‐proBNP) have been measured, and myocardial single‐photon emission computed tomography at rest and on stress was used to define significant myocardial ischemia defined as summed difference score ≥ 2. Myocardial ischemia has been demonstrated in 11 patients (27%, Group A), and 30 patients showed no significant ischemic changes (73%, Group B). The groups did not differ in sex, age, kidney, or liver function. When compared with Group B, Group A had significantly lower LVEF (35 ± 15% in Group A vs. 53 ± 11% in Group B, P < 0.001), higher LVEDV (188 ± 52 mL vs. 136 ± 52 mL, P = 0.007), lower GLS (−9.9 ± 5.2% vs. −14.5 ± 4.1%, P = 0.001), and higher NT‐proBNP levels (1691 ± 1883 pg/mL vs. 422 ± 877 pg/mL, P = 0.006). Overall, higher summed difference score was associated with lower LVEF (r = −0.48, P = 0.001), higher LVEDV (r = 0.39, P = 0.012), lower GLS (r = 0.352, P = 0.024), and higher levels of NT‐proBNP (r = 0.66, P < 0.001). CONCLUSIONS: The presence of myocardial ischemia in patients with NCM is associated with worse left ventricular function, dilation of the left ventricle, and more pronounced neurohumoral activation. John Wiley and Sons Inc. 2020-03-25 /pmc/articles/PMC7261548/ /pubmed/32212326 http://dx.doi.org/10.1002/ehf2.12631 Text en © 2020 The Authors. ESC Heart Failure published by John Wiley & Sons Ltd on behalf of European Society of Cardiology This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Original Research Articles
Cerar, Andraz
Jaklic, Martina
Frljak, Sabina
Poglajen, Gregor
Zemljic, Gregor
Guzic Salobir, Barbara
Dolenc Novak, Maja
Stalc, Monika
Zbacnik, Rok
Kozelj, Mirta
Impairment of myocardial perfusion correlates with heart failure severity in patients with non‐compaction cardiomyopathy
title Impairment of myocardial perfusion correlates with heart failure severity in patients with non‐compaction cardiomyopathy
title_full Impairment of myocardial perfusion correlates with heart failure severity in patients with non‐compaction cardiomyopathy
title_fullStr Impairment of myocardial perfusion correlates with heart failure severity in patients with non‐compaction cardiomyopathy
title_full_unstemmed Impairment of myocardial perfusion correlates with heart failure severity in patients with non‐compaction cardiomyopathy
title_short Impairment of myocardial perfusion correlates with heart failure severity in patients with non‐compaction cardiomyopathy
title_sort impairment of myocardial perfusion correlates with heart failure severity in patients with non‐compaction cardiomyopathy
topic Original Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7261548/
https://www.ncbi.nlm.nih.gov/pubmed/32212326
http://dx.doi.org/10.1002/ehf2.12631
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