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Hepatotoxic pyrrolizidine alkaloids induce DNA damage response in rat liver in a 28-day feeding study

Pyrrolizidine alkaloids (PA) are secondary plant metabolites that occur as food and feed contaminants. Acute and subacute PA poisoning can lead to severe liver damage in humans and animals, comprising liver pain, hepatomegaly and the development of ascites due to occlusion of the hepatic sinusoids (...

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Detalles Bibliográficos
Autores principales:	Ebmeyer, Johanna, Rasinger, Josef Daniel, Hengstler, Jan G., Schaudien, Dirk, Creutzenberg, Otto, Lampen, Alfonso, Braeuning, Albert, Hessel-Pras, Stefanie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2020
Materias:	Organ Toxicity and Mechanisms
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7261731/ https://www.ncbi.nlm.nih.gov/pubmed/32419051 http://dx.doi.org/10.1007/s00204-020-02779-2

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