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Morphometric study of the primary ossification center of the frontal squama in the human fetus
PURPOSES: Detailed morphometric data on the development of ossification centers in human fetuses is useful in the early detection of skeletal dysplasias associated with a delayed development of ossification centers and their mineralization. Quantitative analysis of primary ossification centers of cr...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Paris
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7261738/ https://www.ncbi.nlm.nih.gov/pubmed/32025797 http://dx.doi.org/10.1007/s00276-020-02425-7 |
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author | Grzonkowska, Magdalena Baumgart, Mariusz Badura, Mateusz Wiśniewski, Marcin Szpinda, Michał |
author_facet | Grzonkowska, Magdalena Baumgart, Mariusz Badura, Mateusz Wiśniewski, Marcin Szpinda, Michał |
author_sort | Grzonkowska, Magdalena |
collection | PubMed |
description | PURPOSES: Detailed morphometric data on the development of ossification centers in human fetuses is useful in the early detection of skeletal dysplasias associated with a delayed development of ossification centers and their mineralization. Quantitative analysis of primary ossification centers of cranial bones is sporadic due to limited availability of fetal material. MATERIAL AND METHODS: The size of the primary ossification center of the frontal squama in 37 human (16 males and 21 females) spontaneously aborted human fetuses aged 18–30 weeks was studied by means of CT, digital-image analysis and statistics. RESULTS: With neither sex nor laterality differences, the best-fit growth dynamics for the primary ossification center of the frontal squama was modelled by the following functions: y = 13.756 + 0.021 × (age)(2) ± 0.024 for its vertical diameter, y = 0.956 + 0.956 × age ± 0.823 for its transverse diameter, y = 38.285 + 0.889 × (age)(2) ± 0.034 for its projection surface area, and y = 90.020 + 1.375 × (age)(2) ± 11.441 for its volume. CONCLUSIONS: Our findings for the primary ossification center of the frontal squama may be conducive in monitoring normal fetal growth and screening for inherited faults and anomalies of the skull in human fetuses. |
format | Online Article Text |
id | pubmed-7261738 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Springer Paris |
record_format | MEDLINE/PubMed |
spelling | pubmed-72617382020-06-10 Morphometric study of the primary ossification center of the frontal squama in the human fetus Grzonkowska, Magdalena Baumgart, Mariusz Badura, Mateusz Wiśniewski, Marcin Szpinda, Michał Surg Radiol Anat Original Article PURPOSES: Detailed morphometric data on the development of ossification centers in human fetuses is useful in the early detection of skeletal dysplasias associated with a delayed development of ossification centers and their mineralization. Quantitative analysis of primary ossification centers of cranial bones is sporadic due to limited availability of fetal material. MATERIAL AND METHODS: The size of the primary ossification center of the frontal squama in 37 human (16 males and 21 females) spontaneously aborted human fetuses aged 18–30 weeks was studied by means of CT, digital-image analysis and statistics. RESULTS: With neither sex nor laterality differences, the best-fit growth dynamics for the primary ossification center of the frontal squama was modelled by the following functions: y = 13.756 + 0.021 × (age)(2) ± 0.024 for its vertical diameter, y = 0.956 + 0.956 × age ± 0.823 for its transverse diameter, y = 38.285 + 0.889 × (age)(2) ± 0.034 for its projection surface area, and y = 90.020 + 1.375 × (age)(2) ± 11.441 for its volume. CONCLUSIONS: Our findings for the primary ossification center of the frontal squama may be conducive in monitoring normal fetal growth and screening for inherited faults and anomalies of the skull in human fetuses. Springer Paris 2020-02-05 2020 /pmc/articles/PMC7261738/ /pubmed/32025797 http://dx.doi.org/10.1007/s00276-020-02425-7 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Original Article Grzonkowska, Magdalena Baumgart, Mariusz Badura, Mateusz Wiśniewski, Marcin Szpinda, Michał Morphometric study of the primary ossification center of the frontal squama in the human fetus |
title | Morphometric study of the primary ossification center of the frontal squama in the human fetus |
title_full | Morphometric study of the primary ossification center of the frontal squama in the human fetus |
title_fullStr | Morphometric study of the primary ossification center of the frontal squama in the human fetus |
title_full_unstemmed | Morphometric study of the primary ossification center of the frontal squama in the human fetus |
title_short | Morphometric study of the primary ossification center of the frontal squama in the human fetus |
title_sort | morphometric study of the primary ossification center of the frontal squama in the human fetus |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7261738/ https://www.ncbi.nlm.nih.gov/pubmed/32025797 http://dx.doi.org/10.1007/s00276-020-02425-7 |
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