Cargando…

A New Family of Jumonji C Domain-Containing KDM Inhibitors Inspired by Natural Product Purpurogallin

Aberrant epigenetic modifications are involved in cancer development. Jumonji C domain-containing histone lysine demethylases (KDMs) are found mainly up-regulated in breast, prostate, and colon cancer. Currently, growing interest is focusing on the identification and development of new inhibitors ab...

Descripción completa

Detalles Bibliográficos
Autores principales:	Souto, José A., Sarno, Federica, Nebbioso, Angela, Papulino, Chiara, Álvarez, Rosana, Lombino, Jessica, Perricone, Ugo, Padova, Alessandro, Altucci, Lucia, de Lera, Ángel R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7261929/ https://www.ncbi.nlm.nih.gov/pubmed/32523934 http://dx.doi.org/10.3389/fchem.2020.00312

Ejemplares similares

3-Chloro-N′-(2-hydroxybenzylidene) benzohydrazide: An LSD1-Selective Inhibitor and Iron-Chelating Agent for Anticancer Therapy
por: Sarno, Federica, et al.
Publicado: (2018)

Antiplatelet and antithrombotic activities of purpurogallin in vitro and in vivo
por: Ku, Sae-Kwang, et al.
Publicado: (2014)

Molecular architecture of the Jumonji C family histone demethylase KDM5B
por: Dorosz, Jerzy, et al.
Publicado: (2019)

KDM4 Involvement in Breast Cancer and Possible Therapeutic Approaches
por: Varghese, Benluvankar, et al.
Publicado: (2021)

DOT1L: a key target in normal chromatin remodelling and in mixed-lineage leukaemia treatment
por: Sarno, Federica, et al.
Publicado: (2019)

Jumonji domain‐containing protein 6 protein and its role in cancer
por: Yang, Jing, et al.
Publicado: (2020)

In Silico Insights towards the Identification of NLRP3 Druggable Hot Spots
por: Mekni, Nedra, et al.
Publicado: (2019)

Transcriptional and post-transcriptional control of adipocyte differentiation by Jumonji domain-containing protein 6
por: Hu, Yu-Jie, et al.
Publicado: (2015)

Cooperation between ETS variant 2 and Jumonji domain-containing 2 histone demethylases
por: Li, Xiaomeng, et al.
Publicado: (2018)

Therapeutic Potentials of Inhibition of Jumonji C Domain-containing Demethylases in Acute Myeloid Leukemia
por: Koca, Duygu, et al.
Publicado: (2020)

Kinetic and inhibition studies on human Jumonji-C (JmjC) domain-containing protein 5
por: Tumber, Anthony, et al.
Publicado: (2023)

Dynamic Histone H1 Isotype 4 Methylation and Demethylation by Histone Lysine Methyltransferase G9a/KMT1C and the Jumonji Domain-containing JMJD2/KDM4 Proteins
por: Trojer, Patrick, et al.
Publicado: (2009)

The Jumonji Domain-Containing Histone Demethylase Homolog 1D/lysine Demethylase 7A (JHDM1D/KDM7A) Is an Epigenetic Activator of RHOJ Transcription in Breast Cancer Cells
por: Zhang, Ziyu, et al.
Publicado: (2021)

Inhibitory Effect of Purpurogallin on Osteoclast Differentiation In Vitro through the Downregulation of c-Fos and NFATc1
por: Kim, Kiryeong, et al.
Publicado: (2018)

A molecular threading mechanism underlies Jumonji lysine demethylase KDM2A regulation of methylated H3K36
por: Cheng, Zhongjun, et al.
Publicado: (2014)

Corrigendum: The Jumonji Domain-Containing Histone Demethylase Homolog 1D/lysine Demethylase 7A (JHDM1D/KDM7A) Is an Epigenetic Activator of RHOJ Transcription in Breast Cancer Cells
por: Zhang, Ziyu, et al.
Publicado: (2021)

HIF-1-Dependent Induction of Jumonji Domain-Containing Protein (JMJD) 3 under Hypoxic Conditions
por: Lee, Ho-Youl, et al.
Publicado: (2014)

Jumonji domain-containing 6 (JMJD6) identified as a potential therapeutic target in ovarian cancer
por: Zheng, Heng, et al.
Publicado: (2019)

Jumonji domain-containing protein RIOX2 is overexpressed and associated with worse survival outcomes in prostate cancers
por: He, Chenchen, et al.
Publicado: (2023)

Preclinical and Clinical Epigenetic-Based Reconsideration of Beckwith-Wiedemann Syndrome
por: Papulino, Chiara, et al.
Publicado: (2020)

Involvement of a Jumonji-C domain-containing histone demethylase in DRM2-mediated maintenance of DNA methylation
por: Deleris, Angelique, et al.
Publicado: (2010)

Downregulation of Jumonji-C domain-containing protein 5 inhibits proliferation by silibinin in the oral cancer PDTX model
por: Yang, Cheng-Yu, et al.
Publicado: (2020)

Role of Jumonji domain-containing protein D3 and its inhibitor GSK-J4 in Hashimoto’s thyroiditis
por: Lu, Xixuan, et al.
Publicado: (2023)

Jumonji C Demethylases in Cellular Senescence
por: Leon, Kelly E., et al.
Publicado: (2019)

Purpurogallin Protects Keratinocytes from Damage and Apoptosis Induced by Ultraviolet B Radiation and Particulate Matter 2.5
por: Zhen, Ao Xuan, et al.
Publicado: (2019)

A New Approach for Quantifying Purpurogallin in Brewed Beverages Using LC-MS in Combination with Solid Phase Extraction
por: Liao, Yu-Chen, et al.
Publicado: (2022)

Histone deacetylase controls adult stem cell aging by balancing the expression of polycomb genes and jumonji domain containing 3
por: Jung, Ji-Won, et al.
Publicado: (2010)

The KDM Inhibitor GSKJ4 Triggers CREB Downregulation via a Protein Kinase A and Proteasome-Dependent Mechanism in Human Acute Myeloid Leukemia Cells
por: Illiano, Michela, et al.
Publicado: (2020)

The roles of Jumonji-type oxygenases in human disease
por: Johansson, Catrine, et al.
Publicado: (2014)

Colonic vitamin D receptor expression is inversely associated with disease activity and jumonji domain-containing 3 in active ulcerative colitis
por: Wang, Hong-Qian, et al.
Publicado: (2020)

Jumonji domain-containing protein 2B silencing induces DNA damage response via STAT3 pathway in colorectal cancer
por: Chen, L, et al.
Publicado: (2014)

Jumonji domain-containing protein 6 functions as a marker of head and neck squamous cell carcinoma at advanced stage with no effect on prognosis
por: Guo, Bing, et al.
Publicado: (2019)

Genome-wide identification of the jumonji C domain- containing histone demethylase gene family in wheat and their expression analysis under drought stress
por: Wang, Xinhua, et al.
Publicado: (2022)

Jumonji: Welcome to the World of Interferon Signaling in Alcohol and HCV
por: Moghe, Akshata, et al.
Publicado: (2017)

Purpurogallin, a Natural Phenol, Attenuates High-Mobility Group Box 1 in Subarachnoid Hemorrhage Induced Vasospasm in a Rat Model
por: Chang, Chih-Zen, et al.
Publicado: (2014)

Trifolium Repens Blocks Proliferation in Chronic Myelogenous Leukemia via the BCR-ABL/STAT5 Pathway
por: Sarno, Federica, et al.
Publicado: (2020)

Epigenetic modulator UVI5008 inhibits MRSA by interfering with bacterial gyrase
por: Franci, Gianluigi, et al.
Publicado: (2018)

Jumonji AT-rich interactive domain 1B overexpression is associated with the development and progression of glioma
por: FANG, LIPING, et al.
Publicado: (2016)

Jumonji AT-rich interactive domain 1B overexpression is associated with the development and progression of glioma
por: Fang, Liping, et al.
Publicado: (2016)

FASN multi-omic characterization reveals metabolic heterogeneity in pancreatic and prostate adenocarcinoma
por: Chianese, Ugo, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_6a3o4u4vjq97im4i6meof48ftg