Defactinib attenuates osteoarthritis by inhibiting positive feedback loop between H-type vessels and MSCs in subchondral bone

BACKGROUND: Abnormal bone formation in subchondral bone resulting from uncoupled bone remodeling is considered a central feature in osteoarthritis (OA) pathogenesis. H-type vessels can couple angiogenesis and osteogenesis. We previously revealed that elevated H-type vessels in subchondral bone were...

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Detalles Bibliográficos
Autores principales: Hu, Yanjun, Wu, Hangtian, Xu, Ting, Wang, Yutian, Qin, Hanjun, Yao, Zilong, Chen, Peisheng, Xie, Yongheng, Ji, Zhiguo, Yang, Kaifan, Chai, Yu, Zhang, Xianrong, Yu, Bin, Cui, Zhuang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Chinese Speaking Orthopaedic Society 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7261948/
https://www.ncbi.nlm.nih.gov/pubmed/32518750
http://dx.doi.org/10.1016/j.jot.2020.04.008

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