Natural RNA dependent RNA polymerase inhibitors: Molecular docking studies of some biologically active alkaloids of Argemone mexicana

COVID-19 has become disastrous for world and spread all over. Researchers all around the globe are working to discover a drug to cure from COVID-19. RNA dependent RNA polymerase plays a key role in SARS-CoV-2 replication and thus it could be a potential target for SARS-CoV-2. This study revealed tha...

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Autores principales: Pandeya, K.B., Ganeshpurkar, Aditya, Mishra, Mahendra Kumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7262531/
https://www.ncbi.nlm.nih.gov/pubmed/32535456
http://dx.doi.org/10.1016/j.mehy.2020.109905
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author Pandeya, K.B.
Ganeshpurkar, Aditya
Mishra, Mahendra Kumar
author_facet Pandeya, K.B.
Ganeshpurkar, Aditya
Mishra, Mahendra Kumar
author_sort Pandeya, K.B.
collection PubMed
description COVID-19 has become disastrous for world and spread all over. Researchers all around the globe are working to discover a drug to cure from COVID-19. RNA dependent RNA polymerase plays a key role in SARS-CoV-2 replication and thus it could be a potential target for SARS-CoV-2. This study revealed that Protopine, Allocryptopine and (±) 6- Acetonyldihydrochelerythrine could be potential RdRp inhibitors of SARS-CoV-2.
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spelling pubmed-72625312020-06-01 Natural RNA dependent RNA polymerase inhibitors: Molecular docking studies of some biologically active alkaloids of Argemone mexicana Pandeya, K.B. Ganeshpurkar, Aditya Mishra, Mahendra Kumar Med Hypotheses Article COVID-19 has become disastrous for world and spread all over. Researchers all around the globe are working to discover a drug to cure from COVID-19. RNA dependent RNA polymerase plays a key role in SARS-CoV-2 replication and thus it could be a potential target for SARS-CoV-2. This study revealed that Protopine, Allocryptopine and (±) 6- Acetonyldihydrochelerythrine could be potential RdRp inhibitors of SARS-CoV-2. Elsevier Ltd. 2020-11 2020-06-01 /pmc/articles/PMC7262531/ /pubmed/32535456 http://dx.doi.org/10.1016/j.mehy.2020.109905 Text en © 2020 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Pandeya, K.B.
Ganeshpurkar, Aditya
Mishra, Mahendra Kumar
Natural RNA dependent RNA polymerase inhibitors: Molecular docking studies of some biologically active alkaloids of Argemone mexicana
title Natural RNA dependent RNA polymerase inhibitors: Molecular docking studies of some biologically active alkaloids of Argemone mexicana
title_full Natural RNA dependent RNA polymerase inhibitors: Molecular docking studies of some biologically active alkaloids of Argemone mexicana
title_fullStr Natural RNA dependent RNA polymerase inhibitors: Molecular docking studies of some biologically active alkaloids of Argemone mexicana
title_full_unstemmed Natural RNA dependent RNA polymerase inhibitors: Molecular docking studies of some biologically active alkaloids of Argemone mexicana
title_short Natural RNA dependent RNA polymerase inhibitors: Molecular docking studies of some biologically active alkaloids of Argemone mexicana
title_sort natural rna dependent rna polymerase inhibitors: molecular docking studies of some biologically active alkaloids of argemone mexicana
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7262531/
https://www.ncbi.nlm.nih.gov/pubmed/32535456
http://dx.doi.org/10.1016/j.mehy.2020.109905
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