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The 4th and 112th Residues of Viral Capsid Cooperatively Modulate Capsid-CPSF6 Interactions of HIV-1

Binding of HIV-1 capsid (CA) to cleavage and polyadenylation specificity factor 6 (CPSF6) is hypothesized to provide a significant fitness advantage to in vivo viral replication, explaining why CA-CPSF6 interactions are strictly conserved in primate lentiviruses. We recently identified a Q4R mutatio...

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Detalles Bibliográficos
Autores principales:	Saito, Akatsuki, Sultana, Tahmina, Ode, Hirotaka, Nohata, Kyotaro, Samune, Yoshihiro, Nakayama, Emi E., Iwatani, Yasumasa, Shioda, Tatsuo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Mary Ann Liebert, Inc., publishers 2020
Materias:	Virology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7262650/ https://www.ncbi.nlm.nih.gov/pubmed/31941344 http://dx.doi.org/10.1089/aid.2019.0250

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