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Association between nonalcoholic fatty liver disease and extrahepatic cancers: a systematic review and meta-analysis

BACKGROUND: NAFLD is tightly associated with various diseases such as diabetes, cardiovascular disease, kidney disease, and cancer. Previous studies had investigated the association between NAFLD and various extrahepatic cancers, but the available data to date is not conclusive. The aim of this stud...

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Autores principales: Liu, Shou-Sheng, Ma, Xue-Feng, Zhao, Jie, Du, Shui-Xian, Zhang, Jie, Dong, Meng-Zhen, Xin, Yong-Ning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7262754/
https://www.ncbi.nlm.nih.gov/pubmed/32475354
http://dx.doi.org/10.1186/s12944-020-01288-6
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author Liu, Shou-Sheng
Ma, Xue-Feng
Zhao, Jie
Du, Shui-Xian
Zhang, Jie
Dong, Meng-Zhen
Xin, Yong-Ning
author_facet Liu, Shou-Sheng
Ma, Xue-Feng
Zhao, Jie
Du, Shui-Xian
Zhang, Jie
Dong, Meng-Zhen
Xin, Yong-Ning
author_sort Liu, Shou-Sheng
collection PubMed
description BACKGROUND: NAFLD is tightly associated with various diseases such as diabetes, cardiovascular disease, kidney disease, and cancer. Previous studies had investigated the association between NAFLD and various extrahepatic cancers, but the available data to date is not conclusive. The aim of this study was to investigate the association between NAFLD and various extrahepatic cancers comprehensively. METHODS: Searches were conducted of various electronic databases (PubMed, EMBASE, Medline, and the Cochrane Library) to identify observational studies published between 1996 and January 2020 which investigated the association between NAFLD and extrahepatic cancers. The pooled OR/HR/IRR of the association between NAFLD and various extrahepatic cancers were analyzed. RESULTS: A total of 26 studies were included to investigate the association between NAFLD and various extrahepatic cancers. As the results shown, the pooled OR values of the risk of colorectal cancer and adenomas in patients with NAFLD were 1.72 (95%CI: 1.40–2.11) and 1.37 (95%CI: 1.29–1.46), respectively. The pooled OR values of the risk of intrahepatic cholangiocarcinoma and extrahepatic cholangiocarcinoma in patients with NAFLD were 2.46 (95%CI: 1.77–3.44) and 2.24 (95%CI: 1.58–3.17), respectively. The pooled OR value of the risk of breast cancer in patients with NAFLD was 1.69 (95%CI: 1.44–1.99). In addition, NAFLD was also tightly associatied with the risk of gastric cancer, pancreatic cancer, prostate cancer, and esophageal cancer. CONCLUSIONS: NAFLD could significantly increase the development risk of colorectal adenomas and cancer, intrahepatic and extrahepatic cholangiocarcinoma, breast, gastric, pancreatic, prostate, and esophageal cancer. NAFLD could be considered as one of the influencing factors during the clinical diagnosis and treatment for the extrahepatic cancers.
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spelling pubmed-72627542020-06-07 Association between nonalcoholic fatty liver disease and extrahepatic cancers: a systematic review and meta-analysis Liu, Shou-Sheng Ma, Xue-Feng Zhao, Jie Du, Shui-Xian Zhang, Jie Dong, Meng-Zhen Xin, Yong-Ning Lipids Health Dis Research BACKGROUND: NAFLD is tightly associated with various diseases such as diabetes, cardiovascular disease, kidney disease, and cancer. Previous studies had investigated the association between NAFLD and various extrahepatic cancers, but the available data to date is not conclusive. The aim of this study was to investigate the association between NAFLD and various extrahepatic cancers comprehensively. METHODS: Searches were conducted of various electronic databases (PubMed, EMBASE, Medline, and the Cochrane Library) to identify observational studies published between 1996 and January 2020 which investigated the association between NAFLD and extrahepatic cancers. The pooled OR/HR/IRR of the association between NAFLD and various extrahepatic cancers were analyzed. RESULTS: A total of 26 studies were included to investigate the association between NAFLD and various extrahepatic cancers. As the results shown, the pooled OR values of the risk of colorectal cancer and adenomas in patients with NAFLD were 1.72 (95%CI: 1.40–2.11) and 1.37 (95%CI: 1.29–1.46), respectively. The pooled OR values of the risk of intrahepatic cholangiocarcinoma and extrahepatic cholangiocarcinoma in patients with NAFLD were 2.46 (95%CI: 1.77–3.44) and 2.24 (95%CI: 1.58–3.17), respectively. The pooled OR value of the risk of breast cancer in patients with NAFLD was 1.69 (95%CI: 1.44–1.99). In addition, NAFLD was also tightly associatied with the risk of gastric cancer, pancreatic cancer, prostate cancer, and esophageal cancer. CONCLUSIONS: NAFLD could significantly increase the development risk of colorectal adenomas and cancer, intrahepatic and extrahepatic cholangiocarcinoma, breast, gastric, pancreatic, prostate, and esophageal cancer. NAFLD could be considered as one of the influencing factors during the clinical diagnosis and treatment for the extrahepatic cancers. BioMed Central 2020-05-31 /pmc/articles/PMC7262754/ /pubmed/32475354 http://dx.doi.org/10.1186/s12944-020-01288-6 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Liu, Shou-Sheng
Ma, Xue-Feng
Zhao, Jie
Du, Shui-Xian
Zhang, Jie
Dong, Meng-Zhen
Xin, Yong-Ning
Association between nonalcoholic fatty liver disease and extrahepatic cancers: a systematic review and meta-analysis
title Association between nonalcoholic fatty liver disease and extrahepatic cancers: a systematic review and meta-analysis
title_full Association between nonalcoholic fatty liver disease and extrahepatic cancers: a systematic review and meta-analysis
title_fullStr Association between nonalcoholic fatty liver disease and extrahepatic cancers: a systematic review and meta-analysis
title_full_unstemmed Association between nonalcoholic fatty liver disease and extrahepatic cancers: a systematic review and meta-analysis
title_short Association between nonalcoholic fatty liver disease and extrahepatic cancers: a systematic review and meta-analysis
title_sort association between nonalcoholic fatty liver disease and extrahepatic cancers: a systematic review and meta-analysis
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7262754/
https://www.ncbi.nlm.nih.gov/pubmed/32475354
http://dx.doi.org/10.1186/s12944-020-01288-6
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