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A meta‐analysis of contrast‐enhanced spectral mammography versus MRI in the diagnosis of breast cancer
BACKGROUND: To identify the performance of contrast‐enhanced spectral mammography (CESM) and magnetic resonance imaging (MRI) for breast cancer diagnosis by pooling the open published data. METHODS: A systematic review of studies relevant to CESM and MRI in the diagnosis of breast cancer were screen...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons Australia, Ltd
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7262891/ https://www.ncbi.nlm.nih.gov/pubmed/32233072 http://dx.doi.org/10.1111/1759-7714.13400 |
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author | Xiang, Wanqing Rao, Haiying Zhou, Liyu |
author_facet | Xiang, Wanqing Rao, Haiying Zhou, Liyu |
author_sort | Xiang, Wanqing |
collection | PubMed |
description | BACKGROUND: To identify the performance of contrast‐enhanced spectral mammography (CESM) and magnetic resonance imaging (MRI) for breast cancer diagnosis by pooling the open published data. METHODS: A systematic review of studies relevant to CESM and MRI in the diagnosis of breast cancer were screened in the electronic databases of Pubmed, EMBASE, the Cochrane Library, Web of Science, Google scholar and CNKI. The methodical quality of the included publications was evaluated by the quality assessment of diagnostic accuracy studies‐2 (QUADAS‐2). The diagnostic sensitivity, specificity and area under the ROC curve (AUC) were pooled and the true positive (TP), false positive (FP), false negative (FN) and true negative (TN) of the original studies were calculated. RESULTS: A total of 13 diagnostic publications were identified and included in the meta‐analysis. Of those included, five were retrospective studies and the remaining eight were prospective work. The combined data indicating the pooled sensitivity and specificity of CESM and MRI were 0.97 (95% CI: 0.95–0.98), 0.66 (95% CI: 0.59–0.71), 0.97 (95% CI: 0.95–0.98),and 0.52 (95% CI: 0.46–0.58), respectively. The pooled +LR and –LR for CESM were 2.70 (95% CI: 1.57–4.65), 0.06 (95% CI: 0.04–0.09), and 2.01 (95% CI: 1.78–2.26), 0.08 (95% CI: 0.05–0.11) for MRI, respectively. For the diagnostic odds ratio (DOR), the pooled results of CESM and MRI were 60.15 (95% CI: 24.72–146.37) and 31.34 (95% CI: 19.61–50.08), respectively. The AUC of the symmetric receiver operating characteristic curve (SROC) was 0.9794 and 0.9157 for CESM and MRI, respectively, calculated using the Moses model in the diagnosis of breast cancer. CONCLUSIONS: Both CESM and MRI are effective methods for the detection of breast cancer with high diagnostic sensitivity. The diagnostic performance of CESM appears to be more effective than MRI. |
format | Online Article Text |
id | pubmed-7262891 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | John Wiley & Sons Australia, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-72628912020-06-01 A meta‐analysis of contrast‐enhanced spectral mammography versus MRI in the diagnosis of breast cancer Xiang, Wanqing Rao, Haiying Zhou, Liyu Thorac Cancer Original Articles BACKGROUND: To identify the performance of contrast‐enhanced spectral mammography (CESM) and magnetic resonance imaging (MRI) for breast cancer diagnosis by pooling the open published data. METHODS: A systematic review of studies relevant to CESM and MRI in the diagnosis of breast cancer were screened in the electronic databases of Pubmed, EMBASE, the Cochrane Library, Web of Science, Google scholar and CNKI. The methodical quality of the included publications was evaluated by the quality assessment of diagnostic accuracy studies‐2 (QUADAS‐2). The diagnostic sensitivity, specificity and area under the ROC curve (AUC) were pooled and the true positive (TP), false positive (FP), false negative (FN) and true negative (TN) of the original studies were calculated. RESULTS: A total of 13 diagnostic publications were identified and included in the meta‐analysis. Of those included, five were retrospective studies and the remaining eight were prospective work. The combined data indicating the pooled sensitivity and specificity of CESM and MRI were 0.97 (95% CI: 0.95–0.98), 0.66 (95% CI: 0.59–0.71), 0.97 (95% CI: 0.95–0.98),and 0.52 (95% CI: 0.46–0.58), respectively. The pooled +LR and –LR for CESM were 2.70 (95% CI: 1.57–4.65), 0.06 (95% CI: 0.04–0.09), and 2.01 (95% CI: 1.78–2.26), 0.08 (95% CI: 0.05–0.11) for MRI, respectively. For the diagnostic odds ratio (DOR), the pooled results of CESM and MRI were 60.15 (95% CI: 24.72–146.37) and 31.34 (95% CI: 19.61–50.08), respectively. The AUC of the symmetric receiver operating characteristic curve (SROC) was 0.9794 and 0.9157 for CESM and MRI, respectively, calculated using the Moses model in the diagnosis of breast cancer. CONCLUSIONS: Both CESM and MRI are effective methods for the detection of breast cancer with high diagnostic sensitivity. The diagnostic performance of CESM appears to be more effective than MRI. John Wiley & Sons Australia, Ltd 2020-03-31 2020-06 /pmc/articles/PMC7262891/ /pubmed/32233072 http://dx.doi.org/10.1111/1759-7714.13400 Text en © 2020 The Authors. Thoracic Cancer published by China Lung Oncology Group and John Wiley & Sons Australia, Ltd This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Articles Xiang, Wanqing Rao, Haiying Zhou, Liyu A meta‐analysis of contrast‐enhanced spectral mammography versus MRI in the diagnosis of breast cancer |
title | A meta‐analysis of contrast‐enhanced spectral mammography versus MRI in the diagnosis of breast cancer |
title_full | A meta‐analysis of contrast‐enhanced spectral mammography versus MRI in the diagnosis of breast cancer |
title_fullStr | A meta‐analysis of contrast‐enhanced spectral mammography versus MRI in the diagnosis of breast cancer |
title_full_unstemmed | A meta‐analysis of contrast‐enhanced spectral mammography versus MRI in the diagnosis of breast cancer |
title_short | A meta‐analysis of contrast‐enhanced spectral mammography versus MRI in the diagnosis of breast cancer |
title_sort | meta‐analysis of contrast‐enhanced spectral mammography versus mri in the diagnosis of breast cancer |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7262891/ https://www.ncbi.nlm.nih.gov/pubmed/32233072 http://dx.doi.org/10.1111/1759-7714.13400 |
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