REDD1 loss reprograms lipid metabolism to drive progression of RAS mutant tumors

Human cancers with activating RAS mutations are typically highly aggressive and treatment-refractory, yet RAS mutation itself is insufficient for tumorigenesis, due in part to profound metabolic stress induced by RAS activation. Here we show that loss of REDD1, a stress-induced metabolic regulator,...

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Detalles Bibliográficos
Autores principales: Qiao, Shuxi, Koh, Siang-Boon, Vivekanandan, Varunika, Salunke, Devika, Patra, Krushna Chandra, Zaganjor, Elma, Ross, Kenneth, Mizukami, Yusuke, Jeanfavre, Sarah, Chen, Athena, Mino-Kenudson, Mari, Ramaswamy, Sridhar, Clish, Clary, Haigis, Marcia, Bardeesy, Nabeel, Ellisen, Leif W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7263146/
https://www.ncbi.nlm.nih.gov/pubmed/32273287
http://dx.doi.org/10.1101/gad.335166.119

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