ALS/FTD-associated protein FUS induces mitochondrial dysfunction by preferentially sequestering respiratory chain complex mRNAs

Dysregulation of the DNA/RNA-binding protein FUS causes certain subtypes of ALS/FTD by largely unknown mechanisms. Recent evidence has shown that FUS toxic gain of function due either to mutations or to increased expression can disrupt critical cellular processes, including mitochondrial functions....

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Detalles Bibliográficos
Autores principales: Tsai, Yueh-Lin, Coady, Tristan H., Lu, Lei, Zheng, Dinghai, Alland, Isabel, Tian, Bin, Shneider, Neil A., Manley, James L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7263147/
https://www.ncbi.nlm.nih.gov/pubmed/32381627
http://dx.doi.org/10.1101/gad.335836.119

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